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1. WO2022003565 - DETERGENT AND METHOD FOR PURIFYING A BIOTHERAPEUTIC

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Publication Number WO/2022/003565
Publication Date 06.01.2022
International Application No. PCT/IB2021/055819
International Filing Date 29.06.2021
IPC
C07K 1/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
14Extraction; Separation; Purification
16by chromatography
18Ion-exchange chromatography
C07K 1/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
14Extraction; Separation; Purification
16by chromatography
22Affinity chromatography or related techniques based upon selective absorption processes
C07K 1/36 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
14Extraction; Separation; Purification
36by a combination of two or more processes of different types
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
C07K 1/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
14Extraction; Separation; Purification
36by a combination of two or more processes of different types
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants
  • MEDIMMUNE, LLC [US]/[US]
Inventors
  • HUNTER, Alan
  • ASPELUND, Matthew
  • GADRE, Dhanesh
  • LINKE, Thomas
  • REZVANI, Kamiyar
  • XI, Guoling
Agents
  • MARTIN, Cynthia Lan
Priority Data
63/046,98901.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DETERGENT AND METHOD FOR PURIFYING A BIOTHERAPEUTIC
(FR) DÉTERGENT ET PROCÉDÉ DE PURIFICATION D'UN AGENT BIOTHÉRAPEUTIQUE
Abstract
(EN) Provided herein is an environmentally compatible detergent for use in purification of a recombinantly produced biotherapeutic. The environmentally compatible detergent includes Laureth-9 and can be used for viral clearance, cell lysis, and removal of impurities such as host cell proteins an endotoxins. Advantageously, Laureth-9 does not adversely impact product quality.
(FR) L'invention concerne un détergent compatible avec l'environnement destiné à être utilisé dans la purification d'un agent biothérapeutique produit par recombinaison. Le détergent compatible avec l'environnement comprend du Laureth-9 et peut être utilisé pour la clairance virale, la lyse cellulaire et l'élimination d'impuretés telles que des protéines de cellules hôtes et des endotoxines. Avantageusement, le Laureth-9 ne nuit pas à la qualité du produit.
Latest bibliographic data on file with the International Bureau
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