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1. WO2022003432 - EXTRACT FROM THE RESIN OF THE PROTIUM HEPTAPHYLLUM PLANT, FORMULATIONS COMPRISING SUCH EXTRACT AND HYDROALCOHOLIC EXTRACTION PROCESS AT CONTROLLED PRESSURE AND TEMPERATURE

Publication Number WO/2022/003432
Publication Date 06.01.2022
International Application No. PCT/IB2021/053411
International Filing Date 26.04.2021
IPC
A61K 36/32 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
32Burseraceae (Frankincense family)
A61P 3/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
Applicants
  • ABEL NUTRACEUTICALS SRL [IT]/[IT]
Inventors
  • CAPUZZO, Andrea
  • IOVINO, Piera
  • OCCHIPINTI, Andrea
  • PORCU, Alessandra
  • MANNINO, Giuseppe
Agents
  • MOLA, Edoardo
  • FIUME, Orazio
  • LISA, Elisabetta
Priority Data
10202000001559829.06.2020IT
Publication Language English (en)
Filing Language Italian (IT)
Designated States
Title
(EN) EXTRACT FROM THE RESIN OF THE PROTIUM HEPTAPHYLLUM PLANT, FORMULATIONS COMPRISING SUCH EXTRACT AND HYDROALCOHOLIC EXTRACTION PROCESS AT CONTROLLED PRESSURE AND TEMPERATURE
(FR) EXTRAIT DE RÉSINE DE LA PLANTE PROTIUM HEPTAPHYLLUM, FORMULATIONS COMPRENANT UN TEL EXTRAIT ET PROCÉDÉ D’EXTRACTION HYDROALCOOLIQUE SOUS PRESSION ET TEMPÉRATURE CONTRÔLÉES
Abstract
(EN) The invention relates to a hydroalcoholic extract from the resin of the Protium heptaphyllum plant enriched for the acid triterpene component. The invention also relates to pharmaceutical formulations comprising the aforesaid extract. The invention also relates to a hydroalcoholic extraction process at controlled pressure and temperature of the aforesaid extract. The present invention finds advantageous applications in the inhibition of the gene expression of the HMG-CoA reductase enzyme, in the alteration of the gene expression in liver cells, in the alteration of the gene expression of key factors involved in the lipid metabolism and in the treatment of hypercholesterolemia. Furthermore, the hydroalcoholic extraction process according to the present invention is economically and qualitatively more advantageous than the known solutions thanks to the use of simple and inexpensive equipment as well as of solvents (water and ethanol) non-toxic or anyway widely used at the food level and more environmentally friendly.
(FR) La présente invention concerne un extrait hydroalcoolique provenant de la résine d’une plante Protium heptaphyllum enrichie pour le composant triterpène acide. L’invention concerne également des formulations pharmaceutiques comprenant l’extrait susmentionné. L’invention concerne également un procédé d’extraction hydroalcoolique sous pression et température contrôlées de l’extrait susmentionné. La présente invention trouve des applications avantageuses dans l’inhibition de l’expression génique de l’enzyme HMG-CoA réductase, dans l’altération de l’expression génique dans des cellules hépatiques, dans l’altération de l’expression génique des facteurs clés impliqués dans le métabolisme des lipides et dans le traitement de l’hypercholestérolémie. En outre, le procédé d’extraction hydroalcoolique selon la présente invention est économiquement et qualitativement plus avantageux que les solutions connues dû à l’utilisation d’un équipement simple et bon marché ainsi que de solvants (eau et éthanol) non toxiques ou sinon largement utilisés au niveau alimentaire et plus respectueux de l’environnement.
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