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1. WO2022003225 - SAPPα AND/OR SAPPβ GLYCOSYLATION PATTERN AS A DIAGNOSTIC BIOMARKER OF ALZHEIMER’S DISEASE, AND METHOD AND KIT BASED ON SAME

Publication Number WO/2022/003225
Publication Date 06.01.2022
International Application No. PCT/ES2021/070478
International Filing Date 30.06.2021
IPC
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 33/53 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
C07K 14/47 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/4711
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4711Alzheimer's disease; Amyloid plaque core protein
G01N 2333/4709
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
46from vertebrates
47Assays involving proteins of known structure or function as defined in the subgroups
4701Details
4709Amyloid plaque core protein
G01N 2800/2821
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
28Neurological disorders
2814Dementia; Cognitive disorders
2821Alzheimer
G01N 33/5058
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5044involving specific cell types
5058Neurological cells
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
Applicants
  • UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE [ES]/[ES]
  • CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED [ES]/[ES]
  • CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) [ES]/[ES]
Inventors
  • SÁEZ VALERO, Javier
  • LÓPEZ FONT, Inmaculada Belén
  • CUCHILLO IBÁÑEZ, Inmaculada
  • BOIX RODRÍGUEZ, Claudia Paola
Agents
  • ILLESCAS TABOADA, Manuel
Priority Data
P20203067101.07.2020ES
Publication Language Spanish (es)
Filing Language Spanish (ES)
Designated States
Title
(EN) SAPPα AND/OR SAPPβ GLYCOSYLATION PATTERN AS A DIAGNOSTIC BIOMARKER OF ALZHEIMER’S DISEASE, AND METHOD AND KIT BASED ON SAME
(ES) PATRÓN DE GLICOSILACIÓN DE sAPPα Y/O sAPPβ COMO BIOMARCADOR DIAGNÓSTICO DE LA ENFERMEDAD DE ALZHEIMER, MÉTODO Y KIT BASADOS EN EL MISMO
(FR) MODÈLE DE GLYCOSYLATION DE SAPPα ET/OU SAPPβ COMME BIOMARQUEUR DE DIAGNOSTIC DE LA MALADIE D'ALZHEIMER, MÉTHODE ET TROUSSE REPOSANT SUR CELUI-CI
Abstract
(EN) The invention relates to: an in-vitro method for diagnosing Alzheimer’s disease, wherein the glycosylation pattern of sAPPα and/or sAPPβ in a biological sample is determined; the sAPPα and/or sAPPβ biomarkers for use in the in-vitro method; and an Alzheimer’s disease diagnosis kit, which comprises reagents for determining the sAPPα and/or sAPPβ glycosylation pattern in a biological sample.
(ES) La invención se refiere a un método in vitro de diagnóstico de la enfermedad de Alzheimer en el que se determina el patrón de glicosilación de sAPPα y/o sAPPβ en una muestra biológica, los biomarcadores sAPPα y/o sAPPβ para uso en dicho método in vitro, así como un kit de diagnóstico de la enfermedad de Alzheimer, que comprende reactivos para determinar el patrón de glicosilación de sAPPα y/o sAPPβ en una muestra biológica.
(FR) La présente invention concerne une méthode in vitro de diagnostic de la maladie d'Alzheimer dans laquelle on détermine le modèle de glycosylation de sAPPα et/ou sAPPβ dans un échantillon biologique, les biomarqueurs sAPPα et/ou sAPPβ à utiliser dans ladite méthode in vitro, ainsi qu'une trousse de diagnostic de la maladie d'Alzheimer, qui comprend des réactifs pour déterminer le modèle de glycosylation de sAPPα et/ou sAPPβ dans un échantillon biologique.
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