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1. WO2022003206 - EXTRACELLULAR VESICLES WITH IMPROVED HALF-LIFE

Publication Number WO/2022/003206
Publication Date 06.01.2022
International Application No. PCT/EP2021/068526
International Filing Date 05.07.2021
IPC
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/127 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 47/69 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
Applicants
  • EVOX THERAPEUTICS LTD [GB]/[GB]
Inventors
  • LIANG, Xiuming
  • EL ANDALOUSSI, Samir
Agents
  • COOLEY (UK) LLP
Priority Data
2010278.603.07.2020GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) EXTRACELLULAR VESICLES WITH IMPROVED HALF-LIFE
(FR) VÉSICULES EXTRACELLULAIRES À DEMI-VIE AMÉLIORÉE
Abstract
(EN) The present invention pertains to extracellular vesicles (EVs), wherein the EVs comprise domains present on the surface of the EV, which modify the circulation time of such EVs. Such EVs display improved pharmacokinetics and are therefore useful as therapeutics. Such EVs may also be useful for affinity purification of the EV drug substance.
(FR) La présente invention porte sur des vésicules extracellulaires (VE), les VE comprenant des domaines présents sur la surface des VE, qui modifient le temps de circulation de telles VE. De telles VE présentent une pharmacocinétique améliorée et sont par conséquent utiles en tant qu'agents thérapeutiques. De telles VE peuvent également être utiles pour la purification par affinité de la substance médicamenteuse de VE.
Latest bibliographic data on file with the International Bureau