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1. WO2022003181 - UREA DERIVATIVES OF AMPHOTERICIN AMB, COMPOSITIONS CONTAINING SAME, AND USES THEREOF, ISOCYANATE DERIVATIVES OF OMEGA-AMINO ALKYL, AND USE THEREOF FOR OBTAINING SAID UREA DERIVATIVES

Publication Number WO/2022/003181
Publication Date 06.01.2022
International Application No. PCT/EP2021/068396
International Filing Date 02.07.2021
IPC
C07H 17/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
C07D 295/108 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
10substituted by doubly bound oxygen or sulfur atoms
104with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
108to an acyclic saturated chain
C07C 275/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
04having nitrogen atoms of urea groups bound to acyclic carbon atoms
06of an acyclic and saturated carbon skeleton
C07H 1/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
A61K 31/7048 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
CPC
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
C07C 265/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
265Derivatives of isocyanic acid
02having isocyanate groups bound to acyclic carbon atoms
04of a saturated carbon skeleton
C07D 493/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
08Bridged systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Applicants
  • NANOTRACKS DIAGNOSTICS [FR]/[FR]
Inventors
  • CHERIFI, Kamal
  • BOULHIMEZ, Karim
  • CHAIBI, Najim
Agents
  • AQUINOV
Priority Data
FR200704403.07.2020FR
FR201270604.12.2020FR
Publication Language French (fr)
Filing Language French (FR)
Designated States
Title
(EN) UREA DERIVATIVES OF AMPHOTERICIN AMB, COMPOSITIONS CONTAINING SAME, AND USES THEREOF, ISOCYANATE DERIVATIVES OF OMEGA-AMINO ALKYL, AND USE THEREOF FOR OBTAINING SAID UREA DERIVATIVES
(FR) DERIVÉS URÉE DE L'AMPHOTÉRICINE AMB, COMPOSITIONS LES CONTENANT ET LEURS UTILISATIONS, DÉRIVÉS ISOCYANATE D'ALKYLE OMEGA-AMINÉS ET LEUR UTILISATION POUR OBTENIR LESDITS DÉRIVÉS URÉE
Abstract
(EN) The present invention relates to urea derivatives of polyene macrolides having the following chemical formula: wherein: - R1 is hydrogen or an alkyl or aryl or acyl group, and R2, independently of R1, is hydrogen or an alkyl or aryl or acyl group; or R1 and R2, together with the nitrogen atom to which they are attached, are a radical of a cyclic secondary amine, - R3 is hydrogen or a negative charge or a methyl, ethyl, propyl, or isopropyl group. - R4 is an acid function or hydrogen, - n = 0 to 16, and - m = 0 to 16. The invention further relates to compositions containing these molecules, uses thereof, as well as compounds that have a specific chemical formula and are capable of being used to obtain the molecules having formula Chem 3.
(FR) La présente invention concerne des dérivés urée de macrolides polyéniques présentant la formule chimique suivante: dans laquelle : - R1 représente un hydrogène ou un groupe alkyle ou aryle ou acyle, et R2 représente indépendamment de R1 un hydrogène ou un groupe alkyle ou aryle ou acyle; ou R1 et R2 pris ensemble avec l'atome d'azote auquel ils sont attachés, représentent un radical d'une amine secondaire cyclique,10 - R3 représente un hydrogène ou une charge négative ou un groupe méthyle, éthyle, propyle, ou isopropyle. - R4 représente une fonction acide ou un hydrogène, et - n = 0 à 16, - m = 0 à 16. L'invention a également pour objet les compositions contenant ces molécules, leurs utilisations, ainsi que des composés de formule chimique particulière susceptibles d'être utilisés pour obtenir les molécules de formule Chem 3.
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