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1. WO2022003175 - STABLE EMULSION CONTAINING AN ACTIVE PHARMACEUTICAL INGREDIENT BASED ON N(3-METHYL-2-OXO-2,3-DIHYDROBENZO[D]OXAZOL-5-YL)DODECANAMIDE, PRODUCTION AND USE

Publication Number WO/2022/003175
Publication Date 06.01.2022
International Application No. PCT/EP2021/068380
International Filing Date 02.07.2021
IPC
A61K 9/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 31/423 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
423condensed with carbocyclic rings
A61K 47/10 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols ; Poloxamers; PEG/POE alkyl ethers
A61K 47/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/14 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61P 7/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
10Antioedematous agents; Diuretics
Applicants
  • DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL [DE]/[DE]
Inventors
  • CHRISTIANS, Thorsten
  • KNIE, Ulrich
Agents
  • TER MEER STEINMEISTER & PARTNER PATENTANWÄLTE MBB
Priority Data
20183965.103.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) STABLE EMULSION CONTAINING AN ACTIVE PHARMACEUTICAL INGREDIENT BASED ON N(3-METHYL-2-OXO-2,3-DIHYDROBENZO[D]OXAZOL-5-YL)DODECANAMIDE, PRODUCTION AND USE
(FR) ÉMULSION STABLE CONTENANT UN PRINCIPE ACTIF PHARMACEUTIQUE À BASE DE N(3-MÉTHYL-2-OXO-2,3-DIHYDROBENZO[D]OXAZOL-5-YL)DODÉCANAMIDE, SA FABRICATION ET SON UTILISATION
Abstract
(EN) The present invention relates to an oil-in-water emulsion containing N-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)dodecanamide or a derivative, solvate, hydrate, or prodrug thereof or a pharmaceutically acceptable salt thereof, and a specific emulsifier system. Furthermore, the present invention relates to such an emulsion for use as medicament, in particular for use in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema, pro-allergic or allergic conditions in a patient. Usually, the medicament is a dermatological formulation which is topically applied to the skin or mucosa of a mammal. The present invention also relates to the non-therapeutic (cosmetic) use of the oil-in-water emulsion for treating cosmetic skin conditions and to a method for producing the oil-in-water emulsion.
(FR) La présente invention concerne une émulsion huile dans l'eau contenant du N-(3-méthyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)dodécanamide ou un dérivé, un solvate, un hydrate ou un promédicament de celui-ci ou un sel pharmaceutiquement acceptable de celui-ci, et un système émulsifiant spécifique. En outre, la présente invention concerne une telle émulsion destinée à être utilisée en tant que médicament, en particulier pour le traitement et/ou la prévention d'une inflammation, d'une irritation, d'une démangeaison, d'un prurit, d'une douleur, d'un œdème et d'états pro-allergiques ou allergiques chez un patient. Habituellement, le médicament est une formulation dermatologique qui est appliquée par voie topique sur la peau ou la muqueuse d'un mammifère. La présente invention concerne également l'utilisation non thérapeutique (cosmétique) de l'émulsion huile dans l'eau pour le traitement d'affections cutanées cosmétiques et un procédé de fabrication de l'émulsion huile dans l'eau.
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