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1. WO2022003169 - FGFR1/KLB TARGETING AGONISTIC ANTIGEN-BINDING PROTEINS AND CONJUGATES THEREOF WITH GLP-1R AGONISTIC PEPTIDES

Publication Number WO/2022/003169
Publication Date 06.01.2022
International Application No. PCT/EP2021/068365
International Filing Date 02.07.2021
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61P 3/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • SANOFI [FR]/[FR]
Inventors
  • SOMMERFELD, Mark
  • LANGER, Thomas
  • SCHWAHN, Uwe
  • DITTRICH, Werner
  • RUDOLPH, Christine
  • DREYER, Matthias
  • HÖLPER, Soraya
  • LANGE, Christian
  • LORENZ, Katrin
Agents
  • ALTMANN STÖSSEL DICK PATENTANWÄLTE PARTG MBB
Priority Data
20315336.602.07.2020EP
20315337.402.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) FGFR1/KLB TARGETING AGONISTIC ANTIGEN-BINDING PROTEINS AND CONJUGATES THEREOF WITH GLP-1R AGONISTIC PEPTIDES
(FR) PROTÉINES AGONISTES DE LIAISON À L'ANTIGÈNE CIBLANT FGFR1/KLB ET LEURS CONJUGUÉS AVEC DES PEPTIDES AGONISTES DE GLP-1 R
Abstract
(EN) Provided herein are FGFR1/KLB targeting agonistic antigen-binding proteins, or fragments thereof, having improved physico-chemical properties. Also provided herein are conjugates comprising an FGFR1/KLB targeting agonistic antigen-binding protein, or a fragment thereof, and at least one GLP-1R agonistic peptide. Further provided are pharmaceutical compositions comprising the antibody (or fragment thereof), or the conjugate provided herein, and the use of the antibody (or fragment thereof), or the use of the conjugate in medicine.
(FR) L'invention concerne des protéines agonistes de liaison à l'antigène ciblant FGFR1/KLB, ou des fragments de celles-ci, ayant des propriétés physico-chimiques améliorées. L'invention concerne également des conjugués comprenant une protéine agoniste de liaison à l'antigène ciblant FGFR1/KLB, ou un fragment de celle-ci, et au moins un peptide agoniste de GLP-1R. L'invention concerne en outre des compositions pharmaceutiques comprenant l'anticorps (ou un fragment de celui-ci), ou le conjugué de l'invention, et l'utilisation de l'anticorps (ou d'un fragment de celui-ci), ou l'utilisation du conjugué en médecine.
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