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1. WO2022003152 - COMPOSITIONS COMPRISING EXTRACELLULAR VESICLES AND STING STIMULATORY AGENTS

Publication Number WO/2022/003152
Publication Date 06.01.2022
International Application No. PCT/EP2021/068315
International Filing Date 02.07.2021
IPC
C12N 5/0783 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
A61K 31/7084 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Applicants
  • AARHUS UNIVERSITET [DK]/[DK]
  • REGION MIDTJYLLAND [DK]/[DK]
  • STIPE THERAPEUTICS APS [DK]/[DK]
Inventors
  • HANSEN, Aida Solhøj
  • DELEURAN, Bent Winding
  • JAKOBSEN, Martin Roelsgaard
  • KRAPP, Christian
Agents
  • MEWBURN ELLIS LLP
Priority Data
20183914.903.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS COMPRISING EXTRACELLULAR VESICLES AND STING STIMULATORY AGENTS
(FR) COMPOSITIONS COMPRENANT DES VÉSICULES EXTRACELLULAIRES ET DES AGENTS STIMULATEURS DE PIQÛRE
Abstract
(EN) This present invention describes extracellular vesicles derived from activated T cells can prime macrophages for enhanced pro-inflammatory response towards stimulation with STING agonists. Further, a direct anti-tumoral effect of extracellular vesicles derived from activated T cells prior to intratumorally injection of cGAMP is demonstrated.
(FR) La présente invention concerne des vésicules extracellulaires issues de lymphocytes T activés qui peuvent amorcer des macrophages pour une réponse pro-inflammatoire améliorée vis-à-vis d'une stimulation avec des agonistes de STING. En outre, un effet anti-tumoral direct de vésicules extracellulaires issues de lymphocytes T activés avant injection intratumorale de cGAMP est démontré.
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