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1. WO2022003083 - GORILLA ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF

Publication Number WO/2022/003083
Publication Date 06.01.2022
International Application No. PCT/EP2021/068124
International Filing Date 01.07.2021
IPC
C07K 14/075 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
075Adenoviridae
C12N 15/861 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
861Adenoviral vectors
Applicants
  • REITHERA SRL [IT]/[IT]
Inventors
  • COLLOCA, Stefano
  • LAHM, Armin
  • RAGGIOLI, Angelo
  • VITELLI, Alessandra
Agents
  • ZWICKER, Jörk
Priority Data
20183515.401.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GORILLA ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF
(FR) SÉQUENCES D'ACIDES AMINÉS ET D'ACIDE NUCLÉIQUE D'ADÉNOVIRUS DE GORILLE, VECTEURS LES CONTENANT, ET UTILISATIONS CORRESPONDANTES
Abstract
(EN) The present invention relates to novel adenovirus strains with a high immunogenicity and very low pre-existing immunity in the general human population. The absence of detectable neutralizing antibodies is due to novel hypervariable regions in the adenoviral capsid protein hexon. The present invention provides nucleotide and amino acid sequences of these novel adenovirus strains, as well as recombinant viruses, virus-like particles and vectors based on these strains. Further provided are pharmaceutical compositions and medical uses in the therapy or prophylaxis of a disease, and methods for producing an adenovirus or virus-like particles utilizing the novel sequences, recombinant viruses, virus-like particles and vectors.
(FR) La présente invention concerne de nouvelles souches d'adénovirus présentant une immunogénicité élevée et une immunité préexistante très faible dans la population humaine générale. L'absence d'anticorps neutralisants détectables est dûe à de nouvelles régions hypervariables de la protéine hexon de capside adénovirale. La présente invention concerne des séquences de nucléotides et d'acides aminés de ces nouvelles souches d'adénovirus, ainsi que des virus recombinants, des particules et des vecteurs de type viral basés sur ces souches. L'invention concerne également des compositions pharmaceutiques et des utilisations médicales dans la thérapie ou la prophylaxie d'une maladie, et des méthodes de production d'un adénovirus ou de particules de type viral utilisant les nouvelles séquences, les virus recombinants, les particules et les vecteurs de type viral.
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