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1. WO2022002887 - HUMANIZED ANTIBODIES AGAINST LEWIS Y

Publication Number WO/2022/002887
Publication Date 06.01.2022
International Application No. PCT/EP2021/067767
International Filing Date 29.06.2021
IPC
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
Applicants
  • GLYCOTOPE GMBH [DE]/[DE]
Inventors
  • DANIELCZYK, Antje
  • GELLERT, Johanna
  • FLECHNER, Anke
  • KEHLER, Patrik
Agents
  • HEMSATH, Lars
  • BENIK, Victoria
  • HERTZSCH, Claudia
  • KÖNIG, Gregor
  • LÜCKE, Robert
  • ROTH, Carla
  • SMORODIN, Tobias
  • SZYNKA, Dirk
  • TILMANN, Max W.
  • VERHASSELT, Jörn
  • VON RENESSE, Dorothea
Priority Data
20183237.530.06.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HUMANIZED ANTIBODIES AGAINST LEWIS Y
(FR) ANTICORPS HUMANISÉS CONTRE LEWIS Y
Abstract
(EN) The present invention pertains to humanized anti-Lewis Y antibodies which specifically bind to Lewis Y and do not show any cross-reactivity. Especially, the humanized anti-Lewis Y antibodies do not bind to Lewis b or any other blood group carbohydrate antigen. In particular, the present invention is directed to humanized anti-Lewis Y antibodies which are useful in the treatment of cancer.
(FR) La présente invention concerne des anticorps anti-Lewis Y humanisés qui se lient plus particulièrement à Lewis Y et ne présentent pas de réactivité croisée. En particulier, les anticorps anti-Lewis Y humanisés ne se lient pas à Lewis b ou à tout autre antigène glucidique du groupe sanguin. En particulier, la présente invention est relative à des anticorps anti-Lewis Y humanisés qui sont utiles dans le traitement du cancer.
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