WO2022002780 TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS

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Publication Number WO/2022/002780

Publication Date 06.01.2022

International Application No. PCT/EP2021/067467

International Filing Date 25.06.2021

IPC

Applicants

BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE]/[DE]

Inventors

FLECK, Martin, Thomas
BINDER, Florian, Paul, Christian
WILLWACHER, Jens

Agents

SIMON, Elke, Anna, Maria
SEITZ, Dr. Jürgen

Priority Data

20182987.6

29.06.2020

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS

(FR) DÉRIVÉS DE TÉTRAZOLE UTILES EN TANT QU'INHIBITEURS DE TRPA1

Abstract

(EN) The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

(FR) La présente invention concerne certains dérivés de tétrazole qui sont des inhibiteurs de l'ankyrine à potentiel récepteur transitoire 1 (TRPA1) et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de TRPA1. L'invention concerne également des compositions pharmaceutiques les contenant et des procédés de préparation desdits composés.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535	having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5365	ortho- or peri-condensed with heterocyclic ring systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54	having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535	having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5365	ortho- or peri-condensed with heterocyclic ring systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings

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1. WO2022002780 - TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS