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1. WO2022002154 - FULLY HUMANIZED BISPECIFIC CHIMERIC ANTIGEN RECEPTOR TARGETING CD19 AND CD22 AND USE THEREOF

Publication Number WO/2022/002154
Publication Date 06.01.2022
International Application No. PCT/CN2021/103698
International Filing Date 30.06.2021
IPC
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C12N 5/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C12N 15/62 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 南京驯鹿医疗技术有限公司 NANJING IASO BIOTHERAPEUTICS CO., LTD. [CN]/[CN]
Inventors
  • 杨永坤 YANG, Yongkun
  • 胡广 HU, Guang
  • 谭涛超 TAN, Taochao
  • 戴振宇 DAI, Zhenyu
  • 牛盼盼 NIU, Panpan
  • 孟广荣 MENG, Guangrong
  • 程伟 CHENG, Wei
  • 贾向印 JIA, Xiangyin
  • 莫家露 MO, Jialu
  • 汪文 WANG, Wen
  • 谢白露 XIE, Bailu
  • 杨俊峰 YANG, Junfeng
  • 周飞 ZHOU, Fei
Agents
  • 北京华睿卓成知识产权代理事务所(普通合伙) CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE
Priority Data
202010618929.630.06.2020CN
202010707612.X21.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) FULLY HUMANIZED BISPECIFIC CHIMERIC ANTIGEN RECEPTOR TARGETING CD19 AND CD22 AND USE THEREOF
(FR) RÉCEPTEUR ANTIGÉNIQUE CHIMÉRIQUE BISPÉCIFIQUE ENTIÈREMENT HUMANISÉ CIBLANT CD19 ET CD22 ET SES UTILISATIONS
(ZH) 全人源的靶向CD19和CD22双特异抗原嵌合受体及其应用
Abstract
(EN) Provided is a bispecific chimeric antigen receptor targeting CD19 and CD22, which comprises extracellular antigen binding domains of heavy-chain variable regions and light-chain variable regions of anti-CD19 and anti-CD22 antibodies. Further provided is a bispecific CAR-T cell targeting CD19 and CD22.
(FR) L'invention concerne un récepteur antigénique chimérique bispécifique ciblant CD19 et CD22, qui comprend des domaines de liaison à l'antigène extracellulaire de régions variables de chaîne lourde et de régions variables de chaîne légère d'anticorps anti-CD19 et anti-CD22. L'invention concerne en outre une cellule CAR-T bispécifique ciblant CD19 et CD22.
(ZH) 提供一种靶向CD19和CD22的双特异性嵌合抗原受体,其包括抗CD19和CD22抗体的重链可变区和轻链可变区的胞外抗原结合结构域。还提供了靶向CD19和CD22的双特异CAR-T细胞。
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