Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Tuesday 25.01.2022 at 9:00 AM CET
Settings

Settings

Goto Application

1. WO2022002104 - DIAZENIUMDIOLATE SCHIFF BASE COPPER COMPLEX, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Publication Number WO/2022/002104
Publication Date 06.01.2022
International Application No. PCT/CN2021/103384
International Filing Date 30.06.2021
IPC
C07D 413/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
A61K 31/555 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
555containing heavy metals, e.g. hemin, hematin, melarsoprol
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C12P 17/16 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
16containing two or more hetero rings
C12R 1/465 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1Microorganisms
01Bacteria or actinomycetales
465Streptomyces
Applicants
  • 长沙天赐生物医药科技有限公司 CHANGSHA CHARISM BIOSCIENCES CO., LTD [CN]/[CN]
  • 长沙慈航药物研究所有限公司 CHANGSHA CIHANG RESEARCH CO., LTD [CN]/[CN]
  • 哈药慈航制药股份有限公司 HAYAO CIHANG PHARMACEUTICAL CO., LTD [CN]/[CN]
Inventors
  • 段燕文 DUAN, Yanwen
  • 黄勇 HUANG, Yong
  • 龚邦 GONG, Bang
Agents
  • 长沙正奇专利事务所有限责任公司 CHANGSHA ZONEKEY PATENT LAW FIRM
Priority Data
202010628296.702.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) DIAZENIUMDIOLATE SCHIFF BASE COPPER COMPLEX, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
(FR) COMPLEXE DE CUIVRE BASE DE SCHIFF DIAZÉNIUMDIOLATE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 一种二醇二氮烯鎓席夫碱铜配合物、制备方法及应用
Abstract
(EN) The present invention relates to the technical field of biological medicines, and in particular, to a diazeniumdiolate Schiff base copper complex with a novel structure and a preparation method therefor. Moreover, the present invention further performs preliminary in-vitro test on the biological activity of the diazeniumdiolate schiff base copper complex, and it is found that the diazeniumdiolate schiff base copper complex has obvious cytotoxic activity and gram-positive bacterium resisting activity. The preliminary study on an anti-tumor mechanism of the copper complex is further carried out, and the in vivo anti-tumor test is carried out. The diazeniumdiolate Schiff base copper complex is a natural copper complex containing diazeniumdiolate discovered for the first time, has a good application prospect in the field of biological activities, and can be used as a potential anti-cancer drug and a novel antibacterial agent.
(FR) La présente invention relève du domaine technique des médicaments biologiques, et concerne en particulier un complexe de cuivre base de Schiff diazéniumdiolate ayant une nouvelle structure et son procédé de préparation. De plus, la présente invention réalise en outre un test in vitro préliminaire sur l'activité biologique du complexe de cuivre base de Schiff diazéniumdiolate, et il a été découvert que le complexe de cuivre base de Schiff diazéniumdiolate présente une activité cytotoxique évidente et une activité de résistance à une bactérie à gram positif. L'étude préliminaire sur un mécanisme anti-tumoral du complexe de cuivre est en outre effectuée, et le test anti-tumoral in vivo est réalisé. Le complexe de cuivre base de Schiff diazéniumdiolate est un complexe de cuivre naturel contenant du diazéniumdiolate découvert pour la première fois, qui présente une bonne perspective d'application dans le domaine des activités biologiques, et qui peut être utilisé en tant que médicament anticancéreux potentiel et nouvel agent antibactérien.
(ZH) 本发明涉及生物医药技术领域,具体涉及一种新的结构的二醇二氮烯鎓席夫碱铜配合物及其制备方法。同时本发明还对所述二醇二氮烯鎓席夫碱铜配合物的生物活性进行了初步体外测试,发现其具有明显的细胞毒活性及抗革兰氏阳性菌活性,进一步进行了该铜配合物的抗肿瘤作用机制初步研究并进行了体内抗肿瘤测试。本发明的二醇二氮烯鎓席夫碱铜配合物为首次发现的含二醇二氮烯鎓的天然铜配合物,在生物活性领域具有良好的应用前景,可作为潜在的抗癌药物和新型抗菌剂。
Related patent documents
Latest bibliographic data on file with the International Bureau