Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Tuesday 25.01.2022 at 9:00 AM CET
Settings

Settings

Goto Application

1. WO2022002102 - QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

Publication Number WO/2022/002102
Publication Date 06.01.2022
International Application No. PCT/CN2021/103372
International Filing Date 30.06.2021
IPC
C07D 239/94 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
86with hetero atoms directly attached in position 4
94Nitrogen atoms
C07D 239/80 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
78with hetero atoms directly attached in position 2
80Oxygen atoms
C07D 239/72 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
A61K 31/517 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • INVENTISBIO CO., LTD. [CN]/[CN]
Inventors
  • DAI, Xing
  • WANG, Yaolin
  • JIANG, Yueheng
  • NIU, Haotao
  • LIU, Yanqin
  • YANG, Hong
  • HAN, Zixing
  • WANG, Zhenwu
  • TAO, Liangshan
  • ZHANG, Qiang
  • SHI, Zhe
  • WENG, Jifang
Agents
  • KINGSOUND & PARTNERS
Priority Data
PCT/CN2020/09910430.06.2020CN
PCT/CN2021/07582807.02.2021CN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
(FR) COMPOSÉS DE QUINAZOLINE, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS UTILISATIONS
Abstract
(EN) Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (II), or Formula (III), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer or endometrial cancer.
(FR) L'invention concerne de nouveaux composés, par exemple, des composés représentés par la formule (I), la formule (II) ou la formule (III), ou un sel pharmaceutiquement acceptable de ceux-ci. L'invention concerne également des procédés de préparation de ces composés et des procédés d'utilisation desdits composés, par exemple, dans l'inhibition de KRAS G12D dans une cellule cancéreuse, et/ou dans le traitement de divers cancers tels que le cancer du pancréas, le cancer colorectal, le cancer du poumon ou le cancer de l'endomètre.
Latest bibliographic data on file with the International Bureau