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1. WO2022002040 - LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS

Publication Number WO/2022/002040
Publication Date 06.01.2022
International Application No. PCT/CN2021/103076
International Filing Date 29.06.2021
IPC
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 9/127 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
C12N 15/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
A61K 31/7088 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 47/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
C07F 9/09 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P-C bonds
08Esters of oxyacids of phosphorus
09Esters of phosphoric acids
Applicants
  • SUZHOU ABOGEN BIOSCIENCES CO., LTD. [CN]/[CN]
Inventors
  • YING, Bo
Agents
  • AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE
Priority Data
202010621718.830.06.2020CN
63/049,43108.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS
(FR) COMPOSÉS LIPIDIQUES ET COMPOSITIONS DE NANOPARTICULES LIPIDIQUES
Abstract
(EN) Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipids.
(FR) La présente invention concerne des composés lipidiques qui peuvent être utilisés en combinaison avec d'autres composants lipidiques, tels que des lipides neutres, du cholestérol et des lipides conjugués polymères, pour former des nanoparticules lipidiques pour l'administration d'agents thérapeutiques (par exemple, des molécules d'acide nucléique) à des fins thérapeutiques ou prophylactiques, y compris la vaccination. L'invention concerne également des compositions de nanoparticules lipidiques comprenant lesdits lipides.
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