Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Tuesday 25.01.2022 at 9:00 AM CET
Settings

Settings

Goto Application

1. WO2022001916 - IDH MUTANT INHIBITOR AND USE THEREOF

Publication Number WO/2022/001916
Publication Date 06.01.2022
International Application No. PCT/CN2021/102623
International Filing Date 28.06.2021
IPC
C07D 498/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/5365 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5365ortho- or peri-condensed with heterocyclic ring systems
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 微境生物医药科技(上海)有限公司 WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD. [CN]/[CN]
Inventors
  • 谢雨礼 XIE, Yuli
  • 樊后兴 FAN, Houxing
  • 钱立晖 QIAN, Lihui
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE
Priority Data
202010595326.928.06.2020CN
202110302649.922.03.2021CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) IDH MUTANT INHIBITOR AND USE THEREOF
(FR) INHIBITEUR D'IDH MUTANT ET SON UTILISATION
(ZH) IDH突变体抑制剂及其用途
Abstract
(EN) The present invention relates to a compound of general formula (1a) or general formula (1b) and a preparation method therefor, and use of the compound of general formula (1a) or general formula (1b) and each isomer, each crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof serving as IDH mutant irreversible inhibitors in drug preparation of anti-tumor and other IDH mutant protein related diseases.
(FR) La présente invention concerne un composé de formule générale (1a) ou de formule générale (1b) et un procédé de préparation associé, et l'utilisation du composé de formule générale (1a) ou de formule générale (1b) et chaque isomère, chaque forme cristalline, un sel pharmaceutiquement acceptable, un hydrate ou un solvate de celui-ci servant d'inhibiteurs irréversibles d'IDH mutant dans la préparation de médicament contre des tumeurs et des maladies associées à une protéine d'IDH mutant.
(ZH) 本发明涉及一种通式(1a)或通式(1b)所示的化合物及其制备方法,及通式(1a)或通式(1b)化合物及其各异构体、各晶型、药学上可接受的盐、水合物或溶剂合物作为IDH突变体不可逆抑制剂在抗肿瘤等IDH突变体蛋白相关疾病的药物制备中的用途。
Related patent documents
Latest bibliographic data on file with the International Bureau