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1. WO2022001847 - TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF

Publication Number WO/2022/001847
Publication Date 06.01.2022
International Application No. PCT/CN2021/102261
International Filing Date 25.06.2021
IPC
C07D 413/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
A61K 31/4725 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
A61P 25/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
CPC
A61K 31/4725
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
C07B 2200/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
07Optical isomers
C07D 413/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
Applicants
  • 浙江海正药业股份有限公司 ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. [CN]/[CN]
  • 上海昂睿医药技术有限公司 HISUN ACCURAY THERAPEUTICS CO. LTD [CN]/[CN]
Inventors
  • 郭阳辉 GUO, Yanghui
  • 孟力陈 MENG, Lichen
  • 黄贤贵 HUANG, Xiangui
  • 廖伟伟 LIAO, Weiwei
  • 龚永祥 GONG, Yongxiang
  • 徐代旺 XU, Daiwang
  • 胡泰山 HU, Taishan
  • 陈磊 CHEN, Lei
Agents
  • 北京集佳知识产权代理有限公司 UNITALEN ATTORNEYS AT LAW
Priority Data
202010625224.701.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
(FR) DÉRIVÉ DE TÉTRAHYDROISOQUINOLÉINE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION MÉDICALE
(ZH) 四氢异喹啉类衍生物的盐、其制备方法及其医药应用
Abstract
(EN) The present invention relates to a pharmaceutically acceptable salt of (S)-2-(6-fluorobenzo[d]oxazol-2-yl)-6-methoxy-5-((5-methoxypyridin-2-yl))methoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, a preparation method therefor, a pharmaceutical composition comprising the pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, in particular as an angiotensin II type-2 receptor antagonist.
(FR) La présente invention concerne un sel pharmaceutiquement acceptable de l'acide (S)-2-(6-fluorobenzo[d]oxazol-2-yl)-6-méthoxy-5-((5-méthoxypyridin-2-yl))méthoxy)-1,2,3,4-tétrahydroisoquinoléine-3-carboxylique, son procédé de préparation, une composition pharmaceutique comprenant le sel pharmaceutiquement acceptable de celui-ci, et son utilisation en tant qu'agent thérapeutique, en particulier en tant qu'antagoniste du récepteur de l'angiotensine II type 2.
(ZH) 本发明涉及(S)-2-(6-氟苯并[d]噁唑-2-基)-6-甲氧基-5-((5-甲氧基吡啶-2-基)甲氧基)-1,2,3,4-四氢异喹啉-3-甲酸的可药用盐、其制备方法、包含该可药用盐的药物组合物以及其作为治疗剂特别是作为血管紧张素Ⅱ2型受体拮抗剂的用途。
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