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1. WO2022001255 - CONTRAST AGENT FILM-FORMING AGENT COMPOSITION, CONTRAST AGENT FILM-FORMING LIPID SOLUTION, AND CONTRAST AGENT AND PREPARATION METHOD THEREFOR

Publication Number WO/2022/001255
Publication Date 06.01.2022
International Application No. PCT/CN2021/084087
International Filing Date 30.03.2021
IPC
A61K 49/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparations
A61K 49/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61K 41/00 2020.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 9/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
B82Y 40/00 2011.1
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
40Manufacture or treatment of nanostructures
B82Y 20/00 2011.1
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
20Nanooptics, e.g. quantum optics or photonic crystals
CPC
A61K 41/0057
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
A61K 41/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
A61K 49/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0002General or multifunctional contrast agents, e.g. chelated agents
A61K 49/223
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
A61K 49/226
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
226Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
A61K 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor; ; Other semi-solid forms, e.g. creams, sticks, gels
Applicants
  • 南京超维景生物科技有限公司 NANJING TRANSCEND VIVOSCOPE BIO-TECHNOLOGY CO., LTD [CN]/[CN]
Inventors
  • 董飞宏 DONG, Feihong
  • 安健 AN, Jian
  • 张嘉宾 ZHANG, Jiabin
  • 郭雯雨 GUO, Wenyu
  • 张珏 ZHANG, Jue
Agents
  • 北京布瑞知识产权代理有限公司 BEIJING BRIGHT IP AGENCY CO., LTD.
Priority Data
202010604201.829.06.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CONTRAST AGENT FILM-FORMING AGENT COMPOSITION, CONTRAST AGENT FILM-FORMING LIPID SOLUTION, AND CONTRAST AGENT AND PREPARATION METHOD THEREFOR
(FR) COMPOSITION D'AGENT DE FORMATION DE FILM D'AGENT DE CONTRASTE, SOLUTION DE LIPIDE DE FORMATION DE FILM D'AGENT DE CONTRASTE ET AGENT DE CONTRASTE ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 一种造影剂成膜剂组合物、造影剂成膜脂液、造影剂及其制备方法
Abstract
(EN) The present invention relates to the field of biomedicine, and specifically relates to a contrast agent film-forming agent composition, a contrast agent film-forming lipid solution containing the contrast agent film-forming agent composition, and a contrast agent containing the contrast agent film-forming lipid solution and a preparation method therefor. The contrast agent film-forming agent composition comprises a lipid, an emulsifier and a surface charge modifier. Relative to 100 parts by weight of the lipid, the content of the emulsifier is 20-50 parts by weight, and the content of the surface charge modifier is 10-35 parts by weight, wherein the lipid is a carboxylated phospholipid, and the surface charge modifier is a polyelectrolyte. By means of the composition and the preparation method, nano-droplets of the obtained contrast agent can have a more uniform particle size, higher stability and better controllability, have a lower ultrasonic gasification threshold value, and same can also be used as a photoacoustic contrast agent or a multi-modal contrast agent, and has a wide application prospect.
(FR) La présente invention concerne le domaine de la biomédecine, et concerne plus précisément une composition d'agent de formation de film d'agent de contraste, une solution de lipide de formation de film d'agent de contraste contenant la composition d'agent de formation de film d'agent de contraste, et un agent de contraste contenant la solution de lipide de formation de film d'agent de contraste et son procédé de préparation. La composition d'agent de formation de film d'agent de contraste comprend un lipide, un émulsifiant et un modificateur de charge de surface. Par rapport à 100 parties en poids du lipide, la teneur en émulsifiant est de 20 à 50 parties en poids, et la teneur en modificateur de charge de surface est de 10 à 35 parties en poids, le lipide étant un phospholipide carboxylé, et le modificateur de charge de surface étant un polyélectrolyte. Au moyen de la composition et du procédé de préparation, des nano-gouttelettes de l'agent de contraste obtenu peuvent avoir une taille de particule plus uniforme, une stabilité supérieure et une meilleure aptitude à la commande, ont une valeur de seuil de gazéification ultrasonore réduite, et l'agent de contraste obtenu peut également être utilisé en tant qu'agent de contraste photo-acoustique ou agent de contraste multimodal, et offre de larges perspectives d'application.
(ZH) 涉及生物医药领域,具体涉及一种造影剂成膜剂组合物、含有该造影剂成膜剂组合物的造影剂成膜脂液,含有该造影剂成膜脂液的造影剂及其制备方法。该造影剂成膜剂组合物包括脂质、乳化剂和表面电荷修饰剂,相对于100重量份的所述脂质,所述乳化剂的含量为20-50重量份,所述表面电荷修饰剂的含量为10-35重量份;其中,所述脂质为羧基化的磷脂,所述表面电荷修饰剂为聚电解质。组合物和制备方法能够使得所得的造影剂的纳米液滴具有更均一的粒径、更高的稳定性和更好的可控性,并且具有更低的超声气化阈值,还能够用作光声造影剂或多模态造影剂,具有广阔的应用前景。
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