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1. WO2022001101 - WT1 POLYPEPTIDE TUMOR INHIBITOR

Publication Number WO/2022/001101
Publication Date 06.01.2022
International Application No. PCT/CN2021/074319
International Filing Date 29.01.2021
IPC
C07K 14/47 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 2039/812
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
812Breast
A61K 2039/82
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
82Colon
A61K 39/001153
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
001152Transcription factors, e.g. SOX, c-MYC
001153Wilms tumor 1 [WT1]
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/4748
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
Applicants
  • 维肽瀛(上海)生物技术有限公司 WINLEIN BIOTECH CO., LTD [CN]/[CN]
Inventors
  • 李坤鹏 LI, Kunpeng
Priority Data
202010624208.601.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) WT1 POLYPEPTIDE TUMOR INHIBITOR
(FR) INHIBITEUR TUMORAL POLYPEPTIDIQUE WT1
(ZH) WT1多肽肿瘤抑制剂
Abstract
(EN) Provided is an antigen composed of nine polypeptides from a WT1 protein sequence. In the antigen, a WT1 target is analyzed by computer software, the part of the sequence having the best protein antigenicity is split, and is combined into nine long peptides as an antigen sequence.
(FR) L'invention concerne un antigène composé de neuf polypeptides à partir d'une séquence protéique WT1. Dans l'antigène, une cible WT1 est analysée par un logiciel informatique, la partie de la séquence ayant la meilleure antigénicité protéique est divisée, et est combinée en neuf peptides longs en tant que séquence d'antigène.
(ZH) 提供了一种由9条来自WT1蛋白序列的多肽组成的抗原,其中该抗原是通过计算机软件对WT1靶点进行了分析,将该蛋白抗原性最好的一部分序列进行拆分,组合成为9条长肽作为抗原序列。
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