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1. WO2022001075 - APPLICATIONS OF POSTSYNAPTIC NEUROTOXIN, CARDIOTOXIN, CYTOTOXIN, PHOSPHOLIPASE A2, AND CRUDE TOXIN OF ELAPIDAE SNAKES IN COMBATING VIRAL INFECTIONS

Publication Number WO/2022/001075
Publication Date 06.01.2022
International Application No. PCT/CN2021/000131
International Filing Date 24.06.2021
IPC
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
C07K 14/40 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
37from fungi
39from yeasts
40from Candida
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
A61P 31/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
A61P 31/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
Applicants
  • 沈喆景 SHEN, Zhejing [CN]/[CN]
Inventors
  • 沈喆景 SHEN, Zhejing
Priority Data
202010623330.129.06.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) APPLICATIONS OF POSTSYNAPTIC NEUROTOXIN, CARDIOTOXIN, CYTOTOXIN, PHOSPHOLIPASE A2, AND CRUDE TOXIN OF ELAPIDAE SNAKES IN COMBATING VIRAL INFECTIONS
(FR) APPLICATIONS DE NEUROTOXINE POST-SYNAPTIQUE, DE CARDIOTOXINE, DE CYTOTOXINE, DE PHOSPHOLIPASE A2 ET DE TOXINE BRUTE DE SERPENTS ELAPIDAE DANS LA LUTTE CONTRE DES INFECTIONS VIRALES
(ZH) 眼镜蛇科蛇突触后神经毒素、心脏毒素、细胞毒素、磷脂酶A2及粗毒在抗病毒感染上的应用
Abstract
(EN) Viral infections are main causes of respiratory tract infections in humans and are also causes of hepatitis and AIDS. There are many types of viruses that cause respiratory tract infections, and viruses that cause hepatitis and AIDS mutate frequently; therefore, the use of a medicament allowing the spectral suppression of viruses is clinically an urgent need. A crude toxin of Elapidae snakes and main toxins thereof, namely postsynaptic neurotoxin, cardiotoxin, cytotoxin, and phospholipase A2, serve as membrane toxins (MT) of a membrane active polypeptide; they provide a broad-spectrum virus suppression effect by means of destroying the protein coats of viruses, and thus provide a special meaning and applications in treating diseases caused by virus infections.
(FR) Les infections virales figurent parmi les principales causes d'infections des voies respiratoires chez l'homme, et sont également responsables de l'hépatite et du SIDA. Il existe de nombreux types de virus qui provoquent des infections des voies respiratoires, et les virus qui provoquent l'hépatite et le SIDA mutent fréquemment ; par conséquent, l'utilisation d'un médicament qui permettrait la suppression spectrale de virus représente un besoin clinique urgent. Une toxine brute de serpents Elapidae et ses toxines principales, à savoir une neurotoxine post-synaptique, une cardiotoxine, une cytotoxine et une phospholipase A2, servent de toxines membranaires (MT) d'un polypeptide actif membranaire ; elles fournissent un effet de suppression de virus à large spectre au moyen de la destruction des couches protéiques des virus, et présentent ainsi une signification particulière et des applications dans le traitement de maladies provoquées par des infections virales.
(ZH) 病毒感染是引起人们呼吸道感染的主要原因,同时也是引起肝炎、艾滋病的原因。引起呼吸道感染的病毒有多种,而引起肝炎、艾滋病的这些病毒会经常变异,所以用一种能够光谱抑制病毒的药品已成为临床上的一种急需。眼镜蛇科蛇的粗毒及其主要毒素突触后神经毒素、心脏毒素、细胞毒素、磷脂酶A2,是一种膜活性多肽(membrane active polypeptide)的膜毒素(membrane toxin,MT),它们能通过对病毒蛋白外壳的破坏起着广谱抑制病毒的作用,所以在治疗由病毒感染引起的疾病上有着特殊的意义和应用。
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