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1. WO2022001021 - OPTICAL BIOSENSOR AND COVID-19 VIRUS DETECTION DEVICE

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Publication Number WO/2022/001021
Publication Date 06.01.2022
International Application No. PCT/CN2020/136899
International Filing Date 16.12.2020
IPC
G01N 21/45 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
41Refractivity; Phase-affecting properties, e.g. optical path length
45using interferometric methods; using Schlieren methods
G01N 33/569 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
G01N 2021/458
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
41Refractivity; Phase-affecting properties, e.g. optical path length
45using interferometric methods; using Schlieren methods
458using interferential sensor, e.g. sensor fibre, possibly on optical waveguide
G01N 21/45
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
41Refractivity; Phase-affecting properties, e.g. optical path length
45using interferometric methods; using Schlieren methods
G01N 2333/165
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
G01N 33/56983
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
56983Viruses
Applicants
  • 西湖大学 WESTLAKE UNIVERSITY [CN]/[CN]
Inventors
  • 荣国光 RONG, Guoguang
  • 萨万·默罕默德 SAWAN, Mohamad
  • 卞素敏 BIAN, Sumin
  • 苏逸 SU, Yi
Agents
  • 上海晨皓知识产权代理事务所（普通合伙） SHANGHAI CHENHAO INTELLECTUAL PROPERTY LAW FIRM GENERAL PARTNERSHIP
Priority Data
202010635235.303.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) OPTICAL BIOSENSOR AND COVID-19 VIRUS DETECTION DEVICE
(FR) BIOCAPTEUR OPTIQUE ET DISPOSITIF DE DÉTECTION DE VIRUS COVID-19
(ZH) 光学生物传感器及COVID-19病毒检测装置
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Abstract
(EN) The present application pertains to the technical field of biological detection, and discloses an optical biosensor and a COVID-19 virus detection device. The optical biosensor provided by the present application comprises a single crystal silicon substrate and a nanoporous silicon thin film optical device provided on the single crystal silicon substrate. The nanoporous silicon thin film optical device comprises a porous silicon single-layer interference film, and a porous silicon Bragg reflector or a porous silicon micro-resonant cavity. A composite metal thin film is deposited and a biological probe is coated on the surface of the nanoporous silicon thin film optical device in sequence. The present application significantly improves the detection sensitivity of the optical biosensor by designing the structure of the nanoporous silicon thin film optical device and depositing the composite metal thin film on the surface of the nanoporous silicon thin film optical device, and is applicable to the detection of pathogens such as a COVID-19 virus.
(FR) La présente invention se rapporte au domaine technique de la détection biologique et porte sur un biocapteur optique et sur un dispositif de détection de virus COVID-19. Le biocapteur optique proposé par la présente invention comprend un substrat de silicium monocristallin et un dispositif optique à film mince de silicium nanoporeux disposé sur le substrat de silicium monocristallin. Le dispositif optique à film mince de silicium nanoporeux comprend un film d'interférence monocouche de silicium poreux et un réflecteur de Bragg en silicium poreux ou une cavité micro-résonante en silicium poreux. Un film mince métallique composite est déposé et une sonde biologique est appliquée sur la surface du dispositif optique à film mince de silicium nanoporeux en séquence. La présente invention améliore de manière significative la sensibilité de détection du biocapteur optique en concevant la structure du dispositif optique à film mince de silicium nanoporeux et en déposant le film mince métallique composite sur la surface du dispositif optique à film mince de silicium nanoporeux et est applicable à la détection d'agents pathogènes tels qu'un virus COVID-19.
(ZH) 本申请属于生物检测技术领域，公开了一种光学生物传感器及COVID-19病毒检测装置。本申请所提供的光学生物传感器，包括单晶硅基底及设于所述单晶硅基底上的纳米多孔硅薄膜光学器件，所述纳米多孔硅薄膜光学器件包括多孔硅单层干涉膜、多孔硅布拉格反射镜或多孔硅微谐振腔；所述纳米多孔硅薄膜光学器件的表面依次沉积有复合金属薄膜、包被有生物探针。本申请通过对纳米多孔硅薄膜光学器件的结构设计、以及在纳米多孔硅薄膜光学器件表面沉积复合金属薄膜，显著提高了光学生物传感器的检测灵敏度，适用于对COVID-19病毒等病原体的检测。
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