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1. WO2022001020 - ANTI-B7H3 ANTIBODY AND USE THEREOF

Publication Number WO/2022/001020
Publication Date 06.01.2022
International Application No. PCT/CN2020/136409
International Filing Date 15.12.2020
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
C12N 15/85 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
C12N 5/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
G01N 33/574 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • 广州百暨基因科技有限公司 GUANGZHOU BIO-GENE TECHNOLOGY CO., LTD [CN]/[CN]
Inventors
  • 罗敏 LUO, Min
  • 李光超 LI, Guangchao
  • 周兆 ZHOU, Zhao
  • 王学俊 WANG, Xuejun
Agents
  • 北京品源专利代理有限公司 BEYOND ATTORNEYS AT LAW
Priority Data
202010622482.X30.06.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ANTI-B7H3 ANTIBODY AND USE THEREOF
(FR) ANTICORPS ANTI-B7H3 ET UTILISATION ASSOCIÉE
(ZH) 抗B7H3抗体及其应用
Abstract
(EN) Provided are an anti-B7H3 antibody and the use thereof. A variable region of the antibody comprises amino acid sequences as shown in SEQ ID NOs: 25-39. The anti-B7H3 antibodies 26B6, 6F7, 2B8, and 23H1 have a significant binding capability to B7H3, can not only bind to purified or free B7H3 protein, but also can bind to B7H3 protein on a cell surface; and after humanized modification, the affinity between the antibody and B7H3 is further improved, and the antibody has important application prospects in clinical diagnosis and/or treatment of B7H3-positive tumors.
(FR) L'invention concerne un anticorps anti-B7H3 et une utilisation associée. Une région variable de l'anticorps comprend les séquences d'acides aminés telles que représentées dans les SEQ ID NO : 25-39 Les anticorps anti-B7H3 26B6, 6F7, 2B8 et 23H1 ont une capacité de liaison significative à B7H3, peuvent non seulement se lier à la protéine B7H3 purifiée ou libre, mais aussi se lier à la protéine B7H3 sur une surface cellulaire; et après modification humanisée, l'affinité entre l'anticorps et B7H3 est encore améliorée, et l'anticorps a des perspectives d'application importantes dans le diagnostic clinique et/ou le traitement de tumeurs B7H3-positives.
(ZH) 一种抗B7H3抗体及其应用,所述抗体可变区包括SEQ ID NO:25~39所示的氨基酸序列。所述抗B7H3抗体26B6、6F7、2B8和23H1对B7H3具有显著的结合能力,不仅可以结合纯化的或游离的B7H3蛋白,还可以结合细胞表面的B7H3蛋白;经过人源化改造后,进一步提高了抗体与B7H3的亲和力,在B7H3阳性肿瘤的临床诊断和/或治疗方面具有重要的应用前景。
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