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1. WO2022000884 - MANNOSE-BASED MRNA TARGETED DELIVERY SYSTEM AND USE THEREOF

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Publication Number WO/2022/000884
Publication Date 06.01.2022
International Application No. PCT/CN2020/123993
International Filing Date 27.10.2020
IPC
A61K 31/7115 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
A61K 31/7105 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 31/712 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
712Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
C12N 15/11 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 深圳市瑞吉生物科技有限公司 SHENZHEN RHEGEN BIOMEDICAL TECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 胡勇 HU, Yong
  • 张苗苗 ZHANG, Miaomiao
Agents
  • 北京安信方达知识产权代理有限公司 AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE
Priority Data
202010629898.401.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MANNOSE-BASED MRNA TARGETED DELIVERY SYSTEM AND USE THEREOF
(FR) SYSTÈME D'ADMINISTRATION CIBLÉE D'ARNM À BASE DE MANNOSE ET SON UTILISATION
(ZH) 基于甘露糖的mRNA靶向递送系统及其应用
front page image
Abstract
(EN) Provided are a mannose-based mRNA targeted delivery system and the use thereof, wherein mRNA can encode one or more target polypeptides and includes at least one mannose modification. By means of performing mannose modification on an mRNA molecule, mRNA can be directly coupled with mannose, thereby achieving targeted delivery of mRNA without the need for a vector.
(FR) La présente invention concerne un système d'administration ciblée d'ARNm à base de mannose et son utilisation, l'ARNm pouvant coder pour un ou plusieurs polypeptides cibles et comprenant au moins une modification mannose. En effectuant la modification mannose sur une molécule d'ARNm, l'ARNm peut être directement couplé au mannose, atteignant ainsi l'administration ciblée de l'ARNm sans besoin d'un vecteur.
(ZH) 提供了一种基于甘露糖的mRNA靶向递送系统及其应用，其中mRNA可以编码一种或多种目标多肽并包含至少一个甘露糖修饰。通过对mRNA分子进行甘露糖修饰，从而使得mRNA可以与甘露糖直接偶联，在不需要载体的情况下实现mRNA的靶向递送。
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