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1. WO2022000771 - DRUG FOR INHIBITING BRAIN TUMOR AND APPLICATION THEREOF

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Publication Number WO/2022/000771
Publication Date 06.01.2022
International Application No. PCT/CN2020/113903
International Filing Date 08.09.2020
IPC
A61K 31/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/4188 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4188condensed with heterocyclic ring systems, e.g. biotin, sorbinil
A61K 45/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 31/045 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
CPC
A61K 31/045
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/4188
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
4188condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
Applicants
  • 绿禅生物科技（杭州）有限公司 LVCHAN BIOTECHNOLOGY CO., LTD [CN]/[CN]
Inventors
  • 黄腾飞 HUANG, Tengfei
Agents
  • 北京智丞瀚方知识产权代理有限公司 BEIJING ZHI CHENG HAN FANG IP AGENCY CO., LTD.
Priority Data
202010619931.501.07.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) DRUG FOR INHIBITING BRAIN TUMOR AND APPLICATION THEREOF
(FR) MÉDICAMENT POUR INHIBER UNE TUMEUR CÉRÉBRALE ET SON APPLICATION
(ZH) 一种抑制脑肿瘤的药物及其应用
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Abstract
(EN) The present application provides a drug for inhibiting a brain tumor and an application thereof. The drug for inhibiting a brain tumor comprises at least one TRPV4 agonist capable of promoting calcium ion influx in a TRPV4 signaling channel. The drug provided in the present application has good therapeutic effects on brain tumors and related diseases, and has good application prospect for the treatment of brain tumors and related diseases. The drug provided in the present application, when used in medicaments for the treatment of brain tumors and related diseases, can reduce the toxic and side effects produced during clinical treatment of brain tumors and related diseases, and improve the therapeutic effects of brain tumors and related diseases.
(FR) La présente invention concerne un médicament pour inhiber une tumeur cérébrale et son application. Le médicament pour inhiber une tumeur cérébrale comprend au moins un agoniste TRPV4 capable de favoriser l'afflux d'ions calcium dans un canal de signalisation TRPV4. Le médicament selon la présente invention présente de bons effets thérapeutiques sur des tumeurs cérébrales et des maladies associées, et présente une bonne perspective d'application pour le traitement de tumeurs cérébrales et de maladies associées. Le médicament selon la présente invention, lorsqu'il est utilisé dans des médicaments pour le traitement de tumeurs cérébrales et de maladies associées, peut réduire les effets toxiques et secondaires produits lors du traitement clinique de tumeurs cérébrales et de maladies associées, et améliorer les effets thérapeutiques de tumeurs cérébrales et de maladies associées.
(ZH) 本申请提供一种抑制脑肿瘤的药物及其应用。其中，所述抑制脑肿瘤的药物，其包括能够促进TRPV4信号通道的钙离子内流的至少一种TRPV4激动剂。本申请提供的药物，对脑肿瘤及其相关疾病具有良好的治疗效果，对于脑肿瘤及其相关疾病的治疗具有良好的应用前景。本申请提供的药物，应用于治疗脑肿瘤及其相关疾病的药物中，可以减少脑肿瘤及其相关疾病临床治疗过程中产生的毒副作用，提高脑肿瘤及其相关疾病的治疗效果。
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