Processing

Please wait...

Settings

Settings

Goto Application

1. WO2022000399 - METHYLATED MARKERS FOR ACCURATE DETECTION OF PRIMARY CENTRAL NERVOUS SYSTEM AND SYSTEMIC DIFFUSE LARGE B CELL LYMPHOMA

Publication Number WO/2022/000399
Publication Date 06.01.2022
International Application No. PCT/CN2020/099848
International Filing Date 02.07.2020
IPC
C12Q 1/68 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 45/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
C12Q 1/6886 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Applicants
  • THE JOHNS HOPKINS UNIVERSITY [US]/[US]
  • RENMIN HOSPITAL OF WUHAN UNIVERSITY [CN]/[CN]
Inventors
  • SUKUMAR, Saraswati
  • DOWNS, Bradley
  • DING, Wanjun
  • TAO, Weiping
Agents
  • AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHYLATED MARKERS FOR ACCURATE DETECTION OF PRIMARY CENTRAL NERVOUS SYSTEM AND SYSTEMIC DIFFUSE LARGE B CELL LYMPHOMA
(FR) MARQUEURS MÉTHYLÉS POUR LA DÉTECTION PRÉCISE DU LYMPHOME PRIMITIF DU SYSTÈME NERVEUX CENTRAL ET DU LYMPHOME DIFFUS À GRANDES CELLULES B GÉNÉRALISÉ
Abstract
(EN) Provided are methods for diagnosing and treating diffuse large B-cell lymphoma (DLBCL) and/or primary central nervous system diffuse large B-cell lymphoma (PCNSL). Provided is a set of methylation markers which were identified in silico and confirmed in archival and tissue samples could achieve 100% accuracy to discriminate DLBCL and/or PCNSL from other CNS neoplasms. The markers can be identified using QM-MSP and a simpler, faster, qMSP assay called TAM-MSP.
(FR) Des méthodes de diagnostic et de traitement d'un lymphome diffus à grandes cellules B (DLBCL) et/ou d'un lymphome primitif du système nerveux central à grande cellules B (PCNSL) sont divulgués. La présente invention porte sur un ensemble de marqueurs de méthylation, identifiés in silico et confirmés dans des échantillons d'archives et de tissu pourrait atteindre une précision de 100 % pour distinguer le DLBCL et/ou le PCNSL d'autres néoplasmes du système nerveux central (CNS). Les marqueurs peuvent être identifiés au moyen d'une PCR quantitative multiplex spécifique de la méthylation (QM-MSP) et d'un test qMSP plus simple, plus rapide appelé TAM-MSP.
Latest bibliographic data on file with the International Bureau