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1. WO2022000071 - MATRIX METALLOPROTEINASE INHIBITORS (MMPIS)

Publication Number WO/2022/000071
Publication Date 06.01.2022
International Application No. PCT/CA2021/050063
International Filing Date 21.01.2021
IPC
C07K 5/062 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
062the side chain of the first amino acid being acyclic, e.g. Gly, Ala
A61K 38/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05Dipeptides
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 5/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
CPC
A61K 38/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 5/06043
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06017and aliphatic
06034the side chain containing 2 to 4 carbon atoms
06043Leu-amino acid
Applicants
  • BRANDON UNIVERSITY [CA]/[CA]
Inventors
  • CHEN, Vincent
  • BUSHNELL, Eric
  • HILL, Bryan
Agents
  • MCMANUS, Kimberly A.
  • SINDEN, William K.
  • REECE, Pia-Lauren
  • LOWTHERS, Erica L.
  • BARTOSZEWICZ, Lola A.
  • SABETA, Anton C.
  • CHEUNG, SuMei
Priority Data
63/045,46129.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MATRIX METALLOPROTEINASE INHIBITORS (MMPIS)
(FR) INHIBITEURS DE MÉTALLOPROTÉINASE MATRICIELLE (MMPIS)
Abstract
(EN) Relates to a compound of Formula I a salt, hydrate, solvate, tautomer, enantiomer, racemate, diastereomer, or combination thereof. Also, relates to a compound of Formula II a salt, hydrate, solvate, tautomer, enantiomer, racemate, diastereomer, or combination thereof. The compounds can be a matrix metalloproteinase (MMP) inhibitor. The compounds can also treat a matrix metalloproteinase mediated condition such as cancer.
(FR) L'invention concerne un composé de formule I, un sel, un hydrate, un solvate, un tautomère, un énantiomère, un racémate, un diastéréoisomère ou une combinaison de ceux-ci. L'invention concerne également un composé de formule II, un sel, un hydrate, un solvate, un tautomère, un énantiomère, un racémate, un diastéréoisomère ou une combinaison de ceux-ci. Les composés peuvent être un inhibiteur de métalloprotéinase matricielle (MMP). Les composés peuvent également traiter une affection à médiation par une métalloprotéinase matricielle, telle que le cancer.
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