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1. WO2022000066 - SELF-ASSEMBLED PEPTIDE NANORODS AND USES THEREOF

Publication Number WO/2022/000066
Publication Date 06.01.2022
International Application No. PCT/CA2020/050900
International Filing Date 29.06.2020
IPC
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
A61K 39/385 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
385Haptens or antigens, bound to carriers
A61P 31/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • TRANSFERT PLUS, SOCIÉTÉ EN COMMANDITE [CA]/[CA]
Inventors
  • BOURGAULT, Steve
  • ARCHAMBAULT, Denis
  • ZOTTIG, Ximena
  • AL-HALIFA, Soultan
Agents
  • LAVERY, DE BILLY, LLP
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SELF-ASSEMBLED PEPTIDE NANORODS AND USES THEREOF
(FR) NANOTIGES DE PEPTIDES AUTOASSEMBLÉS ET LEURS UTILISATIONS
Abstract
(EN) Self-assembling, cytocompatible peptides having the ability to form uniform nanorod assemblies are described. These peptides comprise a self-assembling β-sheet peptide and an amino terminal positively charged amino acid or amino acid analog, such as a lysine residue. Constructs comprising an antigen covalently attached to the self-assembling peptide are also disclosed, as well as the use of such constructs as vaccines for inducing an immune response against the antigen.
(FR) L'invention concerne des peptides cytocompatibles à autoassemblage présentant la capacité de former des ensembles nanotiges uniformes. Ces peptides comprennent un peptide de feuille β à autoassemblage et un acide aminé ou un analogue d'acide aminé positivement chargé d'aminé terminal, tel qu'un résidu de lysine. Des constructions comprenant un antigène lié de manière covalente au peptide à autoassemblage sont également divulguées, ainsi que l'utilisation de telles constructions en tant que vaccins pour induire une réponse immunitaire contre l'antigène.
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