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1. WO2021260721 - A NEW COST EFFECTIVE AND SCALABLE PROCESS FOR SYNTHESIZING PURE BRIVARACETAM

Publication Number WO/2021/260721
Publication Date 30.12.2021
International Application No. PCT/IN2021/050594
International Filing Date 19.06.2021
IPC
C07D 207/27 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18having one double bond between ring members or between a ring member and a non-ring member
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24Oxygen or sulfur atoms
262-Pyrrolidones
263with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
27with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
CPC
C07D 207/27
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18having one double bond between ring members or between a ring member and a non-ring member
22with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24Oxygen or sulfur atoms
262-Pyrrolidones
263with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
27with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
Applicants
  • CLININVENT RESEARCH PVT. LTD. [IN]/[IN]
Inventors
  • GHOSH, Angshuman
  • ROY, Sarabindu
  • KUBEER, Ramesh Dhondi
  • PRASAD, Mutyala V. V. Vara
  • MIDYA, Ramkrishna
  • MONDAL, Amit
  • HALDAR, Animesh
  • YADAW, Ajay Kumar
  • ROY, Subho
Agents
  • AMIT JAIN
Priority Data
20203102641423.06.2020IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) A NEW COST EFFECTIVE AND SCALABLE PROCESS FOR SYNTHESIZING PURE BRIVARACETAM
(FR) NOUVEAU PROCÉDÉ RENTABLE ET ÉVOLUTIF POUR LA SYNTHÈSE DE BRIVARACÉTAM PUR
Abstract
(EN) The present invention relates to novel, economical processes for the preparation of enantiomerically pure Brivaracetam of Formula I having 99-100% diastereomeric excess (de) from its (R)-lactone intermediate that is (4R)-4-propyldihydrofuran-2(3H)-one.
(FR) La présente invention concerne de nouveaux procédés économiques pour la préparation de brivaracétam énantiomériquement pur de formule I ayant un excès diastéréomérique (de) de 99 à 100 % à partir de son intermédiaire (R)-lactone qui est le (4R)-4-propyldihydrofuran-2(3H)-one.
Latest bibliographic data on file with the International Bureau