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1. WO2021248046 - MATHEMATICAL MODELING OF BLOOD FLOW TO EVALUATE HEMODYNAMIC SIGNIFICANCE OF PERIPHERAL VASCULAR LEGIONS

Publication Number WO/2021/248046
Publication Date 09.12.2021
International Application No. PCT/US2021/035969
International Filing Date 04.06.2021
IPC
G16H 50/20 2018.1
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
20for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/50 2018.1
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
50for simulation or modelling of medical disorders
G16H 30/40 2018.1
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
30ICT specially adapted for the handling or processing of medical images
40for processing medical images, e.g. editing
G16H 30/20 2018.1
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
30ICT specially adapted for the handling or processing of medical images
20for handling medical images, e.g. DICOM, HL7 or PACS
A61B 5/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/026 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
026Measuring blood flow
CPC
A61B 5/02028
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
02028Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
A61B 5/021
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
021Measuring pressure in heart or blood vessels
A61B 5/026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
026Measuring blood flow
G16H 30/40
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
30ICT specially adapted for the handling or processing of medical images
40for processing medical images, e.g. editing
G16H 50/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
20for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/50
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
50for simulation or modelling of medical disorders
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • MIRRAMEZANI, Seyed Mehran
  • SHADDEN, Shawn
Agents
  • WAGNER, Justin D.
Priority Data
63/034,80104.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MATHEMATICAL MODELING OF BLOOD FLOW TO EVALUATE HEMODYNAMIC SIGNIFICANCE OF PERIPHERAL VASCULAR LEGIONS
(FR) MODÉLISATION MATHÉMATIQUE DE L'ÉCOULEMENT SANGUIN POUR ÉVALUER L'IMPORTANCE HÉMODYNAMIQUE DE LÉSIONS VASCULAIRES PÉRIPHÉRIQUES
Abstract
(EN) A method for non-invasive assessment of peripheral artery disease (PAD) in the peripheral artery/arteries of a patient can include first constructing from medical image data a source model that includes a patient-specific model of the artery/arteries. The method can further include creating a corresponding benchmark model by replacing stenotic segments with idealized segments in the source model and simulating blood flow and blood pressure in the benchmark model to compute reference hemodynamics information. The method can further include generating an assay model by replacing an idealized artery/arteries of interest in the benchmark model with the actual stenotic geometry of the artery/arteries from the source model.
(FR) La présente invention concerne un procédé pour l'évaluation non invasive d'une maladie artérielle périphérique (PAD) dans l'artère/les artères périphérique(s) d'un patient, lequel procédé peut tout d'abord consister à construire, à partir de données d'image médicale, un modèle source qui comprend un modèle spécifique au patient de l'artère/des artères. Le procédé peut en outre consister à créer un modèle de référence correspondant en remplaçant les segments sténosés par des segments idéalisés dans le modèle source et en simulant l'écoulement sanguin et la pression sanguine dans le modèle de référence pour calculer des informations d'hémodynamique de référence. Le procédé peut en outre consister à générer un modèle d'essai en remplaçant une artère/des artères idéalisée(s) d'intérêt dans le modèle de référence par la géométrie sténosée réelle de l'artère/des artères provenant du modèle source.
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