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1. WO2021247953 - COMPOSITIONS AND METHODS FOR TREATING VIRUS INFECTION

Publication Number WO/2021/247953
Publication Date 09.12.2021
International Application No. PCT/US2021/035824
International Filing Date 04.06.2021
IPC
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61K 31/711 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants
  • CHAN ZUCKERBERG BIOHUB, INC. [US]/[US]
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US]
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • FRYDMAN, Judith
  • ANDINO-PAVLOVSKY, Raul
  • AVINER, Ranen
Agents
  • BRUSCA, Eric, M.
Priority Data
63/035,18505.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR TREATING VIRUS INFECTION
(FR) COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT D'UNE INFECTION VIRALE
Abstract
(EN) The present disclosure provides materials and methods for treating or preventing an infection from a virus such as an RNA virus, inhibiting replication of a virus in a cell, inhibiting translation of viral proteins in a cell infected with a virus, inhibiting prolyl hydroxylation in a cell infected with a virus, preventing or inhibiting viral-induced remodeling of a polysome in a cell, and identifying a polysome-associated protein in a cell infected by a virus.
(FR) La présente invention concerne des matériaux et des procédés pour traiter ou prévenir une infection à partir d'un virus tel qu'un virus à ARN, inhiber la réplication d'un virus dans une cellule, inhiber la traduction de protéines virales dans une cellule infectée par un virus, inhiber la prolyl hydroxylation dans une cellule infectée par un virus, prévenir ou inhiber le remodelage induit par un virus d'un polysome dans une cellule, et identifier une protéine associée à un polysome dans une cellule infectée par un virus.
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