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1. WO2021247952 - COMPOSITIONS AND METHODS FOR AUGMENTING AUTOLOGOUS FAT GRAFTS

Publication Number WO/2021/247952
Publication Date 09.12.2021
International Application No. PCT/US2021/035823
International Filing Date 04.06.2021
IPC
A61K 35/12 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 35/35 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
35Fat tissue; Adipocytes; Stromal cells; Connective tissues 
A61L 27/58 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
58Materials at least partially resorbable by the body
A61L 27/26 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
26Mixtures of macromolecular materials
Applicants
  • DUKE UNIVERSITY [US]/[US]
Inventors
  • ROBERTS, Stefan
  • CHILKOTI, Ashutosh
  • KLITZMAN, Bruce
  • HOLLENBECK, Scott
Agents
  • BROWN, Bernard, A., II
  • BROWN, Bernard, A.
Priority Data
63/035,17305.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR AUGMENTING AUTOLOGOUS FAT GRAFTS
(FR) COMPOSITIONS ET MÉTHODES POUR AUGMENTER LES GREFFES DE GRAISSE AUTOLOGUE
Abstract
(EN) Described herein are compositions and method for autologous adipose tissue grafting. In one embodiment, the composition comprises a recombinant partially ordered polypeptide (Fractomer) or "Fractomer" and adipose tissue from a subject. In one aspect, the Fractomer has the general structure of [(GXGVP)n-α-helix]m, where X can be any amino acid except proline and α-helix is any polyalanine based α-helix having about 5 to 50 Alanine residues. In another aspect, the Fractomer has the structure [(GXGVP)n-GX1(A)25X1]m; where X is A or V; X1 is K or D; n is an integer from 10 to 20; and m is an integer from 4 to 8.
(FR) L'invention concerne des compositions et des méthodes pour la greffe de tissus adipeux autologues. Dans un mode de réalisation, la composition comprend un polypeptide recombinant partiellement ordonné ou "Fractomer" et un tissu adipeux d'un sujet. Dans un aspect, le Fractomer a la structure générale [(GXGVP)n-α-hélice]m, où X peut être n'importe quel acide aminé à l'exception de la proline et l'α-hélice est toute α-hélice à base de polyalanine ayant environ de 5 à 50 résidus d'alanine. Dans un autre aspect, le Fractomer a la structure [(GXGVP)n-GX1(A)25X1]m; où X est A ou V; X1 est K ou D; n est un nombre entier de 10 à 20; et m est un nombre entier de 4 à 8.
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