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1. WO2021247794 - B7H3-TARGETING PROTEINS AND METHODS OF USE THEREOF

Publication Number WO/2021/247794
Publication Date 09.12.2021
International Application No. PCT/US2021/035591
International Filing Date 03.06.2021
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/44 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
44against material not provided for elsewhere
Applicants
  • REGENTS OF THE UNIVERSITY OF MINNESOTA [US]/[US]
Inventors
  • FELICES, Martin
  • MILLER, Jeffrey S.
Agents
  • GRAM, Christopher
  • PROVENCE, David
Priority Data
63/033,98903.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) B7H3-TARGETING PROTEINS AND METHODS OF USE THEREOF
(FR) PROTÉINES DE CIBLAGE DE B7H3 ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN) Multispecific B7H3 targeting compounds and methods of use thereof are provided. The multispecific compounds include bispecific targeting proteins including a B7H3 targeting domain and an immune cell engaging domain; and trispecific targeting proteins including a B7H3 targeting domain, an immune cell engaging domain and an immune cell activating domain. The methods of use include methods of inducing NK-mediates cell killing, methods of inducing NK expansion in vivo, and methods of treating cancer.
(FR) L'invention concerne des composés multispécifiques ciblant B7H3. Les composés multispécifiques comprennent des protéines de ciblage bispécifiques comprenant un domaine de ciblage de B7H3 et un domaine de mise en contact de cellules immunitaires; et des protéines de ciblage trispécifiques comprenant un domaine de ciblage de B7H3, un domaine de mise en contact de cellules immunitaires et un domaine d'activation de cellules immunitaires. Les procédés d'utilisation comprennent des procédés d'induction de mort de cellules de médiation de cellules tueuses naturelles (NK), des procédés d'induction d'une expansion de cellules tueuses naturelles (NK) in vivo, et des procédés de traitement du cancer.
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