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1. WO2021247715 - IMMUNOGENIC FRANCISELLA ANTIGENS AND THEIR USE IN IMMUNIZATION OF FISH AGAINST FRANCISELLOSIS

Publication Number WO/2021/247715
Publication Date 09.12.2021
International Application No. PCT/US2021/035461
International Filing Date 02.06.2021
IPC
A61K 39/39 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 9/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61K 39/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
05Corynebacterium; Propionibacterium
CPC
A61K 2039/552
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
55characterised by the host/recipient, e.g. newborn with maternal antibodies
552Veterinary vaccine
A61K 2039/55566
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55566Emulsions, e.g. Freund's adjuvant, MF59
A61K 2039/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
70Multivalent vaccine
A61K 39/0208
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
0208Specific bacteria not otherwise provided for
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
  • THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE [US]/[US]
  • WISYS TECHNOLOGY FOUNDATION, INC. [US]/[US]
  • QUALICUM LABS LTD. [US]/[US]
  • UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US]/[US]
Inventors
  • ROGGE, Matt
  • SOTO MARTINEZ, Esteban
  • LAFRENTZ, Benjamin
  • SHAHIN, Khalid
  • SHRESTHA, Roshan
  • CAMUS, Alvin
Agents
  • DAVY, Brian E.
Priority Data
63/034,28603.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNOGENIC FRANCISELLA ANTIGENS AND THEIR USE IN IMMUNIZATION OF FISH AGAINST FRANCISELLOSIS
(FR) ANTIGÈNES IMMUNOGÈNES DE FRANCISELLA ET LEUR UTILISATION DANS L'IMMUNISATION DE POISSONS CONTRE LA FRANCISELLOSE
Abstract
(EN) Immunogenic compositions that elicit immune responses against Francisella orientalis antigens are provided. In particular, immunogenic compositions comprising Francisella orientalis IglC and/or GroEL immunogenic polypeptides and/or recombinant polynucleotides encoding the Francisella orientalis IglC and/or GroEL immunogenic polypeptides, and/or microalgae expressing the Francisella orientalis IglC and/or GroEL immunogenic polypeptides are provided. Immunogenic compositions may further comprise other Francisella orientalis immunogenic polypeptides and/or immunogenic polypeptides from other pathogens causing disease in fish. The immunogenic compositions may also include one or more adjuvants. Additionally, methods of using the immunogenic compositions in applications including immunization and vaccination are provided.
(FR) L'invention concerne des compositions immunogènes qui déclenchent des réponses immunitaires contre des antigènes de Francisella orientalis. En particulier, des compositions immunogènes comprenant des polypeptides immunogènes de Francisella orientalis IgIC et/ou GroEL et/ou des polynucléotides recombinants codant pour les polypeptides immunogènes de Francisella orientalis IgIC et/ou GroEL, et/ou des microalgues exprimant les polypeptides immunogènes de Francisella orientalis IglC et/ou GroEL. Les compositions immunogènes peuvent en outre comprendre d'autres polypeptides immunogènes de Francisella orientalis et/ou des polypeptides immunogènes provenant d'autres pathogènes provoquant une maladie chez les poissons. Les compositions immunogènes peuvent également comprendre un ou plusieurs adjuvants. De plus, l'invention concerne des procédés d'utilisation des compositions immunogènes dans des applications comprenant l'immunisation et la vaccination.
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