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1. WO2021247534 - COMPOSITIONS AND METHODS FOR TREATING MERKEL CELL CARCINOMA (MCC) USING HLA CLASS I SPECIFIC EPITOPES

Publication Number WO/2021/247534
Publication Date 09.12.2021
International Application No. PCT/US2021/035196
International Filing Date 01.06.2021
IPC
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C07K 16/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
Applicants
  • THE BROAD INSTITUTE, INC. [US]/[US]
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US]
Inventors
  • WU, Catherine J.
  • CARR, Steven
  • KLAEGER, Susan
  • KESKIN, Derin
Agents
  • SCHER, Michael B.
  • NIX, F. Brent
Priority Data
63/033,19101.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR TREATING MERKEL CELL CARCINOMA (MCC) USING HLA CLASS I SPECIFIC EPITOPES
(FR) COMPOSITIONS ET PROCÉDÉS POUR TRAITER UN CARCINOME À CELLULES DE MERKEL (CCM) À L'AIDE D'ÉPITOPES SPÉCIFIQUES DU HLA DE CLASSE I
Abstract
(EN) The subject matter disclosed herein is generally directed to epitopes that specifically bind to subject specific HLA class I molecules in MCC. The epitope identified is specific for MCC and is encoded for in the Merkel Cell Polyomavirus (MCPyV) large T antigen (MCPyV LT).
(FR) L'objet de la présente divulgation concerne, de manière générale, des épitopes qui se lient de façon spécifique à des molécules du HLA de classe I spécifiques d'un sujet dans un CCM. L'épitope identifié est spécifique du CCM et est codé dans le grand antigène T (MCPyV LT) du polyomavirus des cellules de Merkel (MCPyV).
Latest bibliographic data on file with the International Bureau