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1. WO2021247397 - METHODS AND COMPOSITIONS FOR ENHANCING THE IMMUNE SYSTEM

Publication Number WO/2021/247397
Publication Date 09.12.2021
International Application No. PCT/US2021/034777
International Filing Date 28.05.2021
IPC
C07K 16/24 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
C07K 16/44 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
44against material not provided for elsewhere
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A61K 2039/6081
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
6081Albumin; Keyhole limpet haemocyanin [KLH]
A61K 39/0005
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
A61K 39/385
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
385Haptens or antigens, bound to carriers
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
Applicants
  • SIWA CORPORATION [US]/[US]
Inventors
  • GRUBER, Lewis S.
Agents
  • RAUCH, Paul, E.
Priority Data
63/034,92004.06.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR ENHANCING THE IMMUNE SYSTEM
(FR) MÉTHODES ET COMPOSITIONS POUR AMÉLIORER LE SYSTÈME IMMUNITAIRE
Abstract
(EN) A method of enhancing the immune system, treating immunosenescence or preventing immunosenescence comprises administering to a subject a composition comprising an anti-AGE antibody. A method of enhancing the immune system, treating immunosenescence or preventing immunosenescence comprises administering to a subject a vaccine comprising an AGE antigen. A method of killing senescent immune cells in a subject comprises administering to the subject a composition comprising an anti-AGE antibody. The senescent immune cells are selected from the group consisting of white blood cells, mast cells, natural killer cells (NK cells), eosinophils, basophils, gamma/delta T cells (γδ T cells), phagocytic cells, macrophages, neutrophils, dendritic cells, T cells and B cells.
(FR) Une méthode destinée à renforcer le système immunitaire, traiter ou prévenir l'immunosénescence consiste à administrer à un sujet une composition contenant un anticorps anti-AGE. Une méthode destinée à renforcer le système immunitaire, traiter ou prévenir l'immunosénescence consiste à administrer à un sujet un vaccin contenant un antigène anti-AGE. Une méthode de mise à mort de cellules immunitaires sénescentes chez un sujet consiste à administrer audit sujet une composition comprenant un antigène anti-AGE. Les cellules immunitaires sénescentes sont choisies dans le groupe constitué par les globules blancs, les mastocytes, les cellules tueuses naturelles (cellules NK), les éosinophiles, les basophiles, les lymphocytes T gamma/delta (lymphocytes T γδ), les cellules phagocytaires, les macrophages, les neutrophiles, les cellules dendritiques, les lymphocytes T et les lymphocytes B.
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