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1. WO2021242351 - HIGH-THROUGHPUT LABEL-FREE ENZYMATIC BIOASSAYS USING AUTOMATED DESI-MS

Publication Number WO/2021/242351
Publication Date 02.12.2021
International Application No. PCT/US2021/021017
International Filing Date 05.03.2021
IPC
H01J 49/10 2006.1
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
10Ion sources; Ion guns
CPC
G01N 2500/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
G01N 27/622
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
62by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
622Ion mobility spectrometry
G01N 27/626
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
62by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
626using heat to ionise a gas
G01N 27/64
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
62by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
64using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
G01N 33/573
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
573for enzymes or isoenzymes
G01N 33/6851
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
6848Methods of protein analysis involving mass spectrometry
6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
Applicants
  • PURDUE RESEARCH FOUNDATION [US]/[US]
Inventors
  • COOKS, Robert, Graham
  • MORATO, Nicolas, M.
  • HOLDEN, Dylan, T.
Agents
  • SCHOEN, Adam, M.
  • MEYERS, Thomas, C.
  • NICKAS, Mark
  • PALMER, Daniel, A.
  • HYDE, Zachary, D.
Priority Data
63/022,71511.05.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HIGH-THROUGHPUT LABEL-FREE ENZYMATIC BIOASSAYS USING AUTOMATED DESI-MS
(FR) BIOANALYSES ENZYMATIQUES SANS MARQUEUR À HAUT RENDEMENT UTILISANT LA DESI-MS
Abstract
(EN) The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization - mass spectrometry (DESI-MS).
(FR) L'invention concerne de manière générale des bioanalyses enzymatiques sans marqueur à haut rendement utilisant la spectrométrie de masse à désorption-ionisation par électronébulisation (DESI-MS).
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