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1. WO2021240547 - METHODS FOR THE PREPARATION OF SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS AND SOLID FORMS THEREOF

Publication Number WO/2021/240547
Publication Date 02.12.2021
International Application No. PCT/IN2021/050515
International Filing Date 27.05.2021
IPC
C07D 205/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
205Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
C07C 57/15 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
57Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
02with only carbon-to-carbon double bonds as unsaturation
13Dicarboxylic acids
15Fumaric acid
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61K 31/397 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
397having four-membered rings, e.g. azetidine
CPC
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07C 57/15
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
57Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
02with only carbon-to-carbon double bonds as unsaturation
13Dicarboxylic acids
15Fumaric acid
C07D 205/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
205Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
Applicants
  • CIPLA LIMITED [IN]/[IN]
Inventors
  • PATHI, Srinivas Laxminarayan
  • RAVI KUMAR, Puppala
  • CHENNURU, Ramanaiah
  • YARRA, Durga Surya Narayana
  • JAGANNADHAM, Yellanki
  • NANGEDDA, Siva Krishna
  • PULLAREDDY, Lakkireddy
  • BARLA, Raju
Agents
  • P., Aruna Sree
Priority Data
20202102264729.05.2020IN
20202103894709.09.2020IN
20202105003717.11.2020IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR THE PREPARATION OF SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS AND SOLID FORMS THEREOF
(FR) PROCÉDÉS DE PRÉPARATION DE MODULATEURS DU RÉCEPTEUR DE LA SPHINGOSINE 1-PHOSPHATE ET LEURS FORMES SOLIDES
Abstract
(EN) The present invention relates to process for preparation of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxy imino]ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid, intermediates, salts and solid forms thereof to pharmaceutical compositions comprising the salts and solid forms and to use of said compositions for the treatment of multiple sclerosis, particularly secondary progressive multiple sclerosis.
(FR) La présente invention concerne un procédé de préparation de 1-(4-{1-[(E)-4-cyclohexyl-3-trifluorométhyl-benzyloxy imino]éthyl}-2-éthyl-benzyle)-azétidine-3-carboxylique, des intermédiaires, des sels et des formes solides de ceux-ci, des compositions pharmaceutiques comprenant les sels et les formes solides et l'utilisation desdites compositions pour le traitement de la sclérose en plaques, en particulier la sclérose en plaques progressive secondaire.
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