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1. WO2021240519 - INHIBITORS OF AMINO ACIDS TRANSPORTERS AND USE THEREOF

Publication Number WO/2021/240519
Publication Date 02.12.2021
International Application No. PCT/IL2021/050618
International Filing Date 25.05.2021
IPC
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 31/13 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
A61K 31/196 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
196the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 13/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
CPC
A61K 31/196
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
196the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
Applicants
  • HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. [IL]/[IL]
Inventors
  • LEIBOWITZ, Gil
  • KOGOT-LEVINE, Aviram
Agents
  • KESTEN, Dov
  • GEYRA, Assaf
Priority Data
63/029,57125.05.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF AMINO ACIDS TRANSPORTERS AND USE THEREOF
(FR) INHIBITEURS DE TRANSPORTEURS D'ACIDES AMINÉS ET LEUR UTILISATION
Abstract
(EN) The present invention is directed to a pharmaceutical composition including any one of: (i) a S1c6a19 inhibitor; (ii) a S1c7a8 inhibitor; and (iii) a combination of (i) and (ii), and methods of using same, such as for inhibiting or reducing mTOR signaling in a brush border cell, and for treating or preventing fibrosis and/or kidney dysfunction in a subject in need thereof.
(FR) La présente invention concerne une composition pharmaceutique comprenant l'un quelconque parmi : (i) un inhibiteur de S1c6a19; (ii) un inhibiteur de S1c7a8; et (iii) une combinaison de (i) et (ii), et des procédés d'utilisation de ceux-ci, tels que pour inhiber ou réduire la signalisation par mTOR dans une cellule à bordure en brosse, et pour traiter ou prévenir une fibrose et/ou un dysfonctionnement rénal chez un sujet en ayant besoin.
Latest bibliographic data on file with the International Bureau