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1. WO2021239987 - MULTISPECIFIC ANTIBODY

Publication Number WO/2021/239987
Publication Date 02.12.2021
International Application No. PCT/EP2021/064427
International Filing Date 28.05.2021
IPC
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/2809
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2809against the T-cell receptor (TcR)-CD3 complex
C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Applicants
  • NUMAB THERAPEUTICS AG [CH]/[CH]
Inventors
  • LICHTLEN, Peter
  • URECH, David
  • HESS, Christian
  • GUNDE, Tea
  • SIMONIN, Alexandre
  • WARMUTH, Stefan
  • BROCK, Matthias
  • CHATTERJEE, Bithi
  • JOHANSSON, Maria
  • SNELL, Daniel
Agents
  • WALLINGER RICKER SCHLOTTER TOSTMANN
Priority Data
20177337.129.05.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MULTISPECIFIC ANTIBODY
(FR) ANTICORPS MULTISPÉCIFIQUE
Abstract
(EN) The present invention relates to a multispecific antibody comprising two antibody-based binding domains, which specifically binds to mesothelin (MSLN-BD); and at least one antibody-based binding domain, which specifically binds to CD3 (CD3-BD); wherein said multispecific antibody does not comprise an immunoglobulin Fc region polypeptide, and wherein each of said MSLN-BD binds to mesothelin (MSLN) with a monovalent dissociation constant (KD) in the range of from 0.5 to 20 nM, when measured by SPR. The present invention further relates to nucleic acid sequence(s) encoding said multispecific antibody, vector(s) comprising said nucleic acid sequence(s), host cell(s) comprising said nucleic acid sequence(s) or said vector(s), and a method of producing said multispecific antibody. Additionally, the present invention relates to pharmaceutical compositions comprising said multispecific antibody and methods of use thereof.
(FR) La présente invention concerne un anticorps multispécifique comprenant deux domaines de liaison à base d'anticorps qui se lient spécifiquement à la mésothéline (MSLN-BD); et au moins un domaine de liaison à base d'anticorps qui se lie spécifiquement à CD3 (CD3-BD); ledit anticorps multispécifique ne comprenant pas de polypeptide de région Fc d'immunoglobuline, et chacun desdits MSLN-BD se liant à la mésothéline (MSLN) avec une constante de dissociation monovalente (KD) dans la plage de 0,5 à 20 nM, lorsqu'elle est mesurée par RPS. La présente invention concerne en outre une ou plusieurs séquences d'acide nucléique codant pour ledit anticorps multispécifique, un ou plusieurs vecteurs comprenant ladite/lesdites séquence(s) d'acide nucléique, une ou plusieurs cellules hôtes comprenant ladite/lesdites séquence(s) d'acide nucléique ou ledit/lesdits vecteur(s) ainsi qu'une méthode de production dudit anticorps multispécifique. La présente invention concerne également des compositions pharmaceutiques comprenant ledit anticorps multispécifique et des méthodes d'utilisation associées.
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