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1. WO2021239823 - PREVENTING OR TREATING NITRIC OXIDE DEFICIENCY RELATED CONDITIONS

Publication Number WO/2021/239823
Publication Date 02.12.2021
International Application No. PCT/EP2021/064074
International Filing Date 26.05.2021
IPC
A61N 1/36 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
18Applying electric currents by contact electrodes
32alternating or intermittent currents
36for stimulation, e.g. heart pace-makers
A61K 31/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 36/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
CPC
A61K 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
A61K 31/375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
375Ascorbic acid, i.e. vitamin C; Salts thereof
A61K 31/385
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
385having two or more sulfur atoms in the same ring
A61K 31/593
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
A61K 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61K 36/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
Applicants
  • DAAMS, Brechtje Johanna [NL]/[NL]
Inventors
  • DAAMS, Brechtje Johanna
Agents
  • EP&C
Priority Data
202567926.05.2020NL
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PREVENTING OR TREATING NITRIC OXIDE DEFICIENCY RELATED CONDITIONS
(FR) PRÉVENTION OU TRAITEMENT D'ÉTATS LIÉS À UNE DÉFICIENCE EN OXYDE NITRIQUE
Abstract
(EN) The present invention relates to nitrate and/or a nitric oxide donor in combination with N- acetylcysteine and/or N-acetylcysteine amide; and ascorbic acid and/or ascorbate, for use in prevention or treatment of a condition related to nitric oxide deficiency in a patient. In a preferred embodiment the nitrate is inorganic nitrate, and the nitrate and/or a nitric oxide donor is comprised in edible plants or parts, extracts, concentrates thereof, wherein the edible plant is selected from the group comprising: Beta vulgaris, Spinacia oleracea, Eruca sativa, Brassica oleracea, Apium graveolens, Cichorium endivia, Brassica rapa, Brassica sinensis, Lactuca, Foeniculum vulgare, Portulaca oleracea, Rorippa, or any combination thereof. The nitrate and/or a nitric oxide donor may be comprised in Beta vulgaris, preferably Beta vulgaris subsp. vulgaris.
(FR) La présente invention concerne un donneur de nitrate et/ou d'oxyde nitrique en combinaison avec de la N-acétylcystéine et/ou de l'amide de N-acétylcystéine ; et de l'acide ascorbique et/ou de l'ascorbate, à utiliser dans la prévention ou le traitement d'un état lié à une déficience en oxyde nitrique chez un patient. Dans un mode de réalisation préféré, le nitrate est un nitrate inorganique, et le donneur de nitrate et/ou d'oxyde nitrique est compris dans des plantes comestibles ou des parties, extraits, concentrés de celles-ci, la plante comestible étant choisie dans le groupe comprenant : Beta vulgaris, Spinacia oleracea, Eruca sativa, Brassica oleracea, Apium graveolens, Cichorium endivia, Brassica rapa, Brassica sinensis, Lactuca, Foeniculum vulgare, Portulaca oleracea, Rorippa ou toute combinaison de ceux-ci. Le donneur de nitrate et/ou d'oxyde nitrique peut être compris dans Beta vulgaris, de préférence Beta vulgaris subsp. vulgaris.
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