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1. WO2021239471 - CANCER TREATMENT STRATEGIES USING ARENAVIRUS VECTORS

Publication Number WO/2021/239471
Publication Date 02.12.2021
International Application No. PCT/EP2021/062728
International Filing Date 12.05.2021
IPC
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 2039/5254
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5254avirulent or attenuated
A61K 2039/5256
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5256expressing foreign proteins
A61K 2039/5258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5258Virus-like particles
A61K 2039/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/585
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
58raising an immune response against a target which is not the antigen used for immunisation
585wherein the target is cancer
Applicants
  • HOOKIPA BIOTECH GMBH [AT]/[AT]
Inventors
  • MATUSHANSKY, Igor
  • HWANG, Andy
  • KATCHAR, Kianoosh
  • EDWARDS, Donna
  • LAUTERBACH, Henning
  • SCHWENDINGER, Michael
  • ORLINGER, Klaus
  • SCHMIDT, Sarah
  • BERKA, Ursula
  • IACOBUCCI, Corinne
  • SCHLIENGER, Katia
Agents
  • JONES DAY
Priority Data
63/032,36229.05.2020US
63/173,15509.04.2021US
63/175,84216.04.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CANCER TREATMENT STRATEGIES USING ARENAVIRUS VECTORS
(FR) STRATÉGIES DE TRAITEMENT DU CANCER À L'AIDE DE VECTEURS DU TYPE ARÉNAVIRUS
Abstract
(EN) The present application relates generally to cancer treatment strategies using arenavirus particles. The treatment strategies described herein are for treating cancer, including head and neck squamous cell carcinoma, using tri-segmented arenavirus particles encoding a human papillomavirus (HPV) antigen. The treatment strategies described herein can include administration of an immune checkpoint inhibitor.
(FR) La présente demande concerne d'une manière générale des stratégies de traitement du cancer à l'aide de particules d'arénavirus. Les stratégies de traitement décrites dans la description sont destinées à traiter le cancer, notamment le carcinome à cellules squameuses de la tête et du cou, à l'aide de particules d'arénavirus tri-segmentées codant pour un antigène du virus du papillome humain (VPH). Les stratégies de traitement décrites dans la description peuvent comprendre l'administration d'un inhibiteur de point de contrôle immunitaire.
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