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1. WO2021236919 - CELLS AND METHODS FOR PRODUCING METHYL KETONES

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Publication Number WO/2021/236919
Publication Date 25.11.2021
International Application No. PCT/US2021/033382
International Filing Date 20.05.2021
IPC
C12P 7/26 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
24containing a carbonyl group
26Ketones
C12N 9/16 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
C12N 9/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
CPC
C12N 9/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
C12N 9/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
16acting on ester bonds (3.1)
C12N 9/93
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
93Ligases (6)
C12P 7/26
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
24containing a carbonyl group
26Ketones
C12Y 101/01035
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
101Oxidoreductases acting on the CH-OH group of donors (1.1)
01with NAD+ or NADP+ as acceptor (1.1.1)
010353-Hydroxyacyl-CoA dehydrogenase (1.1.1.35)
C12Y 203/01016
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
203Acyltransferases (2.3)
01transferring groups other than amino-acyl groups (2.3.1)
01016Acetyl-CoA C-acyltransferase (2.3.1.16)
Applicants
  • WISCONSIN ALUMNI RESEARCH FOUNDATION [US]/[US]
Inventors
  • PFLEGER, Brian F.
  • YAN, Qiang
  • SIMMONS, Trevor R.
  • HERNANDEZ-LOZADA, Nestor
Agents
  • BLASIOLE, Daniel
  • FIESCHKO, Craig
  • LEONE, Joseph T.
  • MIOTKE, Joseph T.
  • NEAL, Elizabeth
  • SARA, Charles S.
  • SCHERER, Christopher
  • BLOCK, Erin
Priority Data
63/027,87220.05.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CELLS AND METHODS FOR PRODUCING METHYL KETONES
(FR) CELLULES ET PROCÉDÉS DE PRODUCTION DE MÉTHYLCÉTONES
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Abstract
(EN) Recombinant cells and methods for producing methyl ketones, such as medium-chain methyl ketones. The recombinant cells include recombinant acyl-ACP thioesterase genes, recombinant β-ketoacyl-CoA thioesterase genes, and recombinant acyl-CoA synthetase genes, in addition to other modifications. The methods include culturing the recombinant cells to produce the methyl ketones and isolating the produced methyl ketones.
(FR) L'invention concerne des cellules recombinées et des procédés pour produire des méthylcétones, telles que des méthylcétones à chaîne moyenne. Les cellules recombinées comprennent des gènes recombinés d'acyl-ACP thioestérase, des gènes recombinés de β-cétoacyl-CoA thioestérase, et des gènes recombinés d'acyl-CoA synthétase, en plus d'autres modifications. Les procédés comprennent la culture des cellules recombinées pour produire les méthylcétones et l'isolement des méthylcétones produites.
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