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1. WO2021236023 - FERMENTED - CONCENTRATED EXTRACTION METHOD OF HOUTTUYNIA CORDATA FOR MEDICAL USING

Publication Number WO/2021/236023
Publication Date 25.11.2021
International Application No. PCT/TH2020/000057
International Filing Date 11.08.2020
IPC
A61K 36/064 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
06Fungi, e.g. yeasts
062Ascomycota
064Saccharomycetales, e.g. baker's yeast
A61K 36/78 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
78Saururaceae (Lizard's-tail family)
A61K 35/744 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61K 35/747 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
A61P 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
CPC
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A23L 33/135
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
135Bacteria or derivatives thereof, e.g. probiotics
A23L 33/14
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
14Yeasts or derivatives thereof
A61K 2236/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
A61K 35/744
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61K 35/747
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
Applicants
  • RINCOME, Udom [TH]/[TH]
Inventors
  • RINCOME, Udom
  • RINCOME, Somsak
Priority Data
200100271518.05.2020TH
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) FERMENTED - CONCENTRATED EXTRACTION METHOD OF HOUTTUYNIA CORDATA FOR MEDICAL USING
(FR) PROCÉDÉ D'EXTRACTION FERMENTÉE - CONCENTRÉE DE HOUTTUYNIA CORDATA POUR UTILISATION MÉDICALE
Abstract
(EN) Methods of fermentation and extraction of concentrated herbs in order to get more active pharmaceutical ingredients has been done by taking none defected and clean Plukow leaf in clean water, rinse thoroughly and let drain. Then put it into the fermentation tank. Weigh sugar cane powder, add starters namely Saccharomyces cerevisiae, Lactobacillus casei (GenBank: AF320255.1), Lactobacillus plantarum (GenBank: AF320256.1) in another tank, add clean water to sufficient 1,000 litres, stir thoroughly, then pour the mixture to the first fermentation tank to flood over the Plukow leaf. Close the lid tightly and expose the fermentation tank in the sun light for 1 month. Remove the leaves from the fermented water, dry in a hot air oven at 100° (degrees Celsius) then grind into fine powder. Mix the fine powder with fermented water in ratio of 1:2 weight by weight in roasting tank, ignite the head of the gas stove to heat the wet powder to reach 100-150° while the roasting tank rotates slowly for 1 hour. After that, dries the powder in hot air oven for 100° for 8-12 hours, then mix the powder with the leftover fermented water as the same procedure mentioned above until fermented water in the tank exhausted. The concentrated Plukow extracts with more quercetin and beta glucan will be obtained. This concentrated herb extracts can be used for active pharmaceutical ingredient in medical herb or food supplement.
(FR) Des procédés de fermentation et d'extraction d'herbes concentrées afin d'obtenir des ingrédients pharmaceutiques plus actifs ont été réalisés de la manière suivante : mettre des feuilles de Plukow propres et sans défauts dans de l'eau propre, les rincer soigneusement et les laisser s'égoutter. Puis les placer dans la cuve de fermentation. Peser la poudre de canne à sucre, ajouter des amorces, à savoir Saccharomyces cerevisiae, Lactobacillus casei (GenBank : AF320255.1), Lactobacillus plantarum (GenBank : AF320256.1) dans une autre cuve, ajouter de l'eau propre à une quantité suffisante de 1 000 litres, agiter soigneusement, puis verser le mélange dans la première cuve de fermentation pour inonder la feuille de Plukow. Fermer le couvercle de manière étanche et exposer la cuve de fermentation au soleil pendant 1 mois. Éliminer les feuilles de l'eau fermentée, les sécher dans un four à air chaud à 100° (degrés Celsius), puis les broyer en poudre fine. Mélanger la poudre fine avec de l'eau fermentée dans un rapport de 1:2 en poids dans la cuve de torréfaction, allumer la tête de la cuisinière à gaz pour chauffer la poudre humide pour atteindre 100-150° tandis que la cuve de torréfaction tourne lentement pendant 1 heure. Après cela, sécher la poudre dans un four à air chaud à 100° pendant 8 à 12 heures, puis mélanger la poudre avec l'eau fermentée restante comme la même procédure mentionnée ci-dessus jusqu'à ce que l'eau fermentée dans la cuve soit épuisée. Les extraits de Plukow concentrés avec plus de quercétine et de beta-glucane sont obtenus. Ces extraits d'herbes concentrées peuvent être utilisés pour un ingrédient pharmaceutique actif dans des herbes médicinales ou des compléments alimentaires.
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