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1. WO2021234668 - SYSTEM, METHOD AND USE OF A CERTAIN MEDICATION FOR REDUCING VIRAL REPLICATION IN THE AIRWAYS MUCOSAE

Publication Number WO/2021/234668
Publication Date 25.11.2021
International Application No. PCT/IB2021/054451
International Filing Date 21.05.2021
IPC
A61K 31/133 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
133having hydroxy groups, e.g. sphingosine
A61K 31/135 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
A61K 31/137 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
CPC
A61K 31/573
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573substituted in position 21, e.g. cortisone, dexamethasone, prednisone ; or aldosterone
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61K 9/0078
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
0078for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Applicants
  • RIVEROS, Carlos Alberto [CO]/[US]
Inventors
  • RIVEROS, Carlos Alberto
Agents
  • OLARTE, Carlos R.
Priority Data
63/028,71422.05.2020US
63/182,12530.04.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SYSTEM, METHOD AND USE OF A CERTAIN MEDICATION FOR REDUCING VIRAL REPLICATION IN THE AIRWAYS MUCOSAE
(FR) SYSTÈME, PROCÉDÉ ET UTILISATION D'UN CERTAIN MÉDICAMENT POUR RÉDUIRE LA RÉPLICATION VIRALE DANS LES MUQUEUSES DES VOIES RESPIRATOIRES
Abstract
(EN) A system, method, use, combination and kits useful in the administration of a certain medication for reducing viral replication of certain viruses during the early stage of transmission or as a prophylaxis when high risk of exposure to a virus is detected or predicted, administering efficiently a high local concentration of the certain medication while minimizing systemic exposure. Specifically it refers to a system, a method, a use, pharmaceutical combination and pharmaceutical kits of a certain nebulized medication to reduce viral replication. The development uses inhalers or nebulizers to deliver at least one certain medication directly into the upper and lower airways mucosae.
(FR) L'invention concerne un système, un procédé, une utilisation, une combinaison et des kits se révélant utiles dans l'administration d'un certain médicament permettant de réduire la réplication virale de certains virus pendant l'étape précoce de transmission ou en tant que prophylaxie lorsqu'un risque élevé d'exposition à un virus est détecté ou prédit, par l'administration efficace d'une concentration locale élevée du certain médicament tout en réduisant au minimum l'exposition systémique. Spécifiquement, l'invention concerne un système, un procédé, une utilisation, une combinaison pharmaceutique et des kits pharmaceutiques d'un certain médicament nébulisé afin de réduire la réplication virale. L’invention utilise des inhalateurs ou des nébuliseurs pour administrer au moins un certain médicament directement dans les muqueuses des voies respiratoires supérieures et inférieures.
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