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1. WO2021234592 - SITE-SPECIFIC CONJUGATION OF GLYCOSYLATED MONOCLONAL ANTIBODIES WITH TRANSGLUTAMINASE

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Publication Number WO/2021/234592
Publication Date 25.11.2021
International Application No. PCT/IB2021/054308
International Filing Date 19.05.2021
IPC
C07K 16/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A61K 47/68 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/32 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
32against translation products from oncogenes
Applicants
  • JANSSEN BIOTECH, INC. [US]/[US]
Inventors
  • DUDKIN, Vadim
  • GOLDBERG, Shalom
  • MCCAULEY, Michael J.
  • WILEY, Kristen
  • WISSNER, Rebecca
Agents
  • SHIRTZ, Joseph F.
  • HORNINGER, Lisa Mead
Priority Data
63/027,39620.05.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SITE-SPECIFIC CONJUGATION OF GLYCOSYLATED MONOCLONAL ANTIBODIES WITH TRANSGLUTAMINASE
(FR) CONJUGAISON SPÉCIFIQUE À UN SITE D'ANTICORPS MONOCLONAUX GLYCOSYLÉS AVEC LA TRANSGLUTAMINASE
Abstract
(EN) Engineered antibodies useful for site-specific conjugation by a transglutaminase are described. Also described are methods of site-specific conjugation of the antibodies, the site-specifically conjugated antibodies, and pharmaceutical compositions and uses related to the site-specifically conjugated antibodies.
(FR) L'invention concerne des anticorps modifiés utiles pour une conjugaison spécifique à un site par une transglutaminase. L'invention concerne également des procédés de conjugaison spécifique à un site des anticorps, les anticorps conjugués spécifiquement à un site et des compositions pharmaceutiques et des utilisations associées aux anticorps conjugués spécifiquement à un site.
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