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1. WO2021229359 - PROCESS FOR THE PREPARATION SALTS OF TRIAZOLE COMPOUNDS

Publication Number WO/2021/229359
Publication Date 18.11.2021
International Application No. PCT/IB2021/053696
International Filing Date 04.05.2021
IPC
C07D 403/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
C07D 405/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
A61K 31/496 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
Applicants
  • CELLIX BIO PRIVATE LIMITED [IN]/[IN]
Inventors
  • KANDULA, Mahesh
Agents
  • THOMAS, Santhamma
Priority Data
20204101995112.05.2020IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION SALTS OF TRIAZOLE COMPOUNDS
(FR) PROCÉDÉ DE PRÉPARATION DE SELS DE COMPOSÉS DE TRIAZOLE
Abstract
(EN) The present invention discloses a large scale process for preparation of triazole compounds using polar and non-polar solvents. More particularly relates to s method of preparing dilauryl glyceryl fumarate salt of posaconazole, voriconazole and itraconazole respectively. The method comprises of dissolving triazole compound and dilauryl glyceryl fumarate in a suitable polar solvent at a temperature range of 30-55℃ for salt formation and final salt is isolated using non-polar solvent at a low temperature range of 0-35℃. It further discloses a method of producing fine particulate size of the dilauryl glyceryl fumarate salt of triazole preferably in the size ranging from 0.001micron to 100micron. It also discloses a method of preparing a desired pharmaceutical preparation.
(FR) La présente invention concerne un procédé à grande échelle pour la préparation de composés de triazole en utilisant des solvants polaires et non polaires. Plus particulièrement, l'invention concerne un procédé de préparation de sel dilauryl glycéryl fumarate de posaconazole, de voriconazole et d'itraconazole respectivement. Le procédé comprend la dissolution d'un composé de triazole et de dilauryl glycéryl fumarate dans un solvant polaire approprié à une plage de température de 30 à 55 °C pour la formation de sel et le sel final est isolé à l'aide d'un solvant non polaire en utilisant une plage de température basse de 0 à 35 °C. L'invention concerne en outre un procédé de production de la taille particulaire fine du sel de dilauryl glycéryl fumarate de triazole de préférence une plage de tailles allant de 0,001 micron à 100 microns. L'invention concerne également un procédé de préparation d'une préparation pharmaceutique souhaitée.
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