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1. WO2021226627 - REDUCTION OF CYTOKINE STORM AND PATHOLOGICAL INFLAMMATION INCLUDING CAUSED BY CORONAVIRUS USING SPHAGNUM AND EXTRACTS THEREOF

Publication Number WO/2021/226627
Publication Date 11.11.2021
International Application No. PCT/US2021/070504
International Filing Date 04.05.2021
IPC
A01G 22/00 2018.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
GHORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
22Cultivation of specific crops or plants not otherwise provided for
A01G 22/30 2018.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
GHORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
22Cultivation of specific crops or plants not otherwise provided for
30Moss
A61K 36/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
CPC
A01G 22/30
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
GHORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
22Cultivation of specific crops or plants not otherwise provided for
30Moss
A61K 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61K 36/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
10Bryophyta
Applicants
  • FIGENE, LLC [US]/[US]
Inventors
  • O'HEERON, Pete
  • ICHIM, Thomas
Agents
  • SISTRUNK, Melissa
Priority Data
63/020,19805.05.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) REDUCTION OF CYTOKINE STORM AND PATHOLOGICAL INFLAMMATION INCLUDING CAUSED BY CORONAVIRUS USING SPHAGNUM AND EXTRACTS THEREOF
(FR) RÉDUCTION DE LA TEMPÊTE DE CYTOKINES ET DE L'INFLAMMATION PATHOLOGIQUE NOTAMMENT PROVOQUÉE PAR LE CORONAVIRUS À L'AIDE DE SPHAIGNE ET EXTRAITS DE CELLE-CI
Abstract
(EN) Disclosed are treatments, compositions of matter, and protocols for reducing, ameliorating, or reversing excess inflammation and/or cytokine storm through administration of Sphagnum and/or extracts thereof. In particular embodiments, a patient at risk for cytokine storm is administered a Sphagnum extract at a concentration sufficient to induce an immunomodulatory change in said patient, including suppression of macrophage activation, reduction of neutrophil activation and inhibition of DNA extracellular trap release. In some embodiments, Sphagnum, or extracts thereof are administered together with other agents to enhance activity in treatment of Covid-19 infection and associated pathologies. In some embodiments, humic acid and/or analogues thereof are administered for reduction of pathological inflammation and/or stimulation of immunity.
(FR) Des traitements, des compositions de matière et des protocoles pour réduire, améliorer ou inverser une inflammation excessive et/ou une tempête de cytokines par l'administration de sphaigne et/ou d'extraits de celle-ci sont divulgués. Dans des modes de réalisation particuliers, un patient présentant un risque de tempête de cytokines se voit administrer un extrait de sphaigne à une concentration suffisante pour induire un changement immunomodulateur chez ledit patient, comprenant la suppression de l'activation des macrophages, la réduction de l'activation des neutrophiles et l'inhibition de la libération de piège extracellulaire d'ADN. Dans certains modes de réalisation, la sphaigne ou des extraits de celle-ci sont administrés conjointement avec d'autres agents pour améliorer l'activité dans le traitement d'une infection par la Covid-19 et de pathologies associées. Dans certains modes de réalisation, un acide humique et/ou des dérivés de celui-ci sont administrés pour la réduction de l'inflammation pathologique et/ou la stimulation de l'immunité.
Latest bibliographic data on file with the International Bureau