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1. WO2021220099 - SEMI-SOLID FORMULATION FOR VOLUNTARY ORAL ADMINISTRATION OF BIOACTIVE COMPOUNDS TO RODENTS

Publication Number WO/2021/220099
Publication Date 04.11.2021
International Application No. PCT/IB2021/053124
International Filing Date 15.04.2021
IPC
A61K 9/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A23K 10/30 2016.1
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
KFEEDING-STUFFS SPECIALLY ADAPTED FOR ANIMALS; METHODS SPECIALLY ADAPTED FOR PRODUCTION THEREOF
10Animal feeding-stuffs
30from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
A61K 31/40 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/4985 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/505 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A01N 25/08 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
08containing solids as carriers or diluents
CPC
A01N 25/004
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, ; e.g. seed treatment or sequential application;
002containing a foodstuff as carrier or diluent, i.e. baits
004rodenticidal
A23K 10/16
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
KFODDER
10Animal feeding-stuffs
10obtained by microbiological or biochemical processes
16Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
A23K 10/18
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
KFODDER
10Animal feeding-stuffs
10obtained by microbiological or biochemical processes
16Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
18of live microorganisms
A23K 10/22
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
KFODDER
10Animal feeding-stuffs
20from material of animal origin
22from fish
A23K 10/30
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
KFODDER
10Animal feeding-stuffs
30from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
A23K 10/33
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
KFODDER
10Animal feeding-stuffs
30from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
33from molasses
Applicants
  • UNIVERSIDADE DE COIMBRA [PT]/[PT]
  • INSTITUTO POLITÉCNICO DE COIMBRA [PT]/[PT]
Inventors
  • DOMINGUES VIANA, Sofia Andreia
  • FERNANDES REIS, Flávio Nelson
Agents
  • VIEIRA PEREIRA FERREIRA, Maria Silvina
Priority Data
11630127.04.2020PT
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SEMI-SOLID FORMULATION FOR VOLUNTARY ORAL ADMINISTRATION OF BIOACTIVE COMPOUNDS TO RODENTS
(FR) FORMULATION SEMI-SOLIDE DESTINÉE À L’ADMINISTRATION ORALE VOLONTAIRE DE COMPOSÉS BIOACTIFS À DES RONGEURS
Abstract
(EN) This application relates to a formulation for voluntary oral administration of bioactive compounds to rodents. The semid-solid formulation disclosed in the presente patent application comprises at least one thickening agent, a digestible sweetener selected from sucralose and calcium saccharin, a diluent agent, wherein the diluent agent is a powder with a granulometry between 300 and 800µm, obtained from finely grounded seeds, cereal grains or cereal grain based diet for rodents, at least one flavor masking agent and a bioactive compound. The presently disclosed semi-solid formulation has shown promote voluntary feeding in rodents regardless of the bioactive compounds contained therein and without disruption of the metabolic pathways, therefore said semi-solid formulation has shown to be ideal for use in the oral administration of drugs and bioactive compounds to rodents. Use of said semi-solid formulation in the production of toxicant baits for rodents is also envisioned.
(FR) La présente invention se rapporte à une formulation destinée à l’administration orale volontaire de composés bioactifs à des rongeurs. La formulation semi-solide selon la présente divulgation concerne au moins un agent épaississant, un édulcorant digeste sélectionné parmi le sucralose et la saccharine calcique, un agent diluant, l’agent diluant étant une poudre ayant une granulométrie comprise entre 300 et 800 µm, obtenue à partir de graines finement broyées, des grains de céréales ou un régime à base de grains de céréales destinés aux rongeurs, au moins un agent de masquage d’arôme et un composé bioactif. La formulation semi-solide selon la présente divulgation a démontré une alimentation volontaire favorisée chez les rongeurs quels que soient les composés bioactifs contenus à l’intérieur et sans rupture des voies métaboliques, par conséquent ladite formulation semi-solide s’est montrée comme idéale pour être utilisée dans l’administration orale de médicaments et de composés bioactifs à des rongeurs. L’utilisation de ladite formulation semi-solide dans la production d’appâts toxiques destinés aux rongeurs est également envisagée.
Latest bibliographic data on file with the International Bureau