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1. WO2021217788 - METHOD FOR PREPARING COMPOUND-TYPE TABLETS FOR PROTECTING LIVER AND DISPELLING EFFECTS OF ALCOHOL

Publication Number WO/2021/217788
Publication Date 04.11.2021
International Application No. PCT/CN2020/094908
International Filing Date 08.06.2020
IPC
A61K 36/899 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
88Liliopsida (monocotyledons)
899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
A61P 1/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 13/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61K 9/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 9/51 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
CPC
A61K 2236/331
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
33involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
331using water, e.g. cold water, infusion, tea, steam distillation, decoction
A61K 2236/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
39Complex extraction schemes, e.g. fractionation or repeated extraction steps
A61K 31/357
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
357having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
A61K 36/068
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
06Fungi, e.g. yeasts
062Ascomycota
066Clavicipitaceae
068Cordyceps
A61K 36/288
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
288Taraxacum (dandelion)
A61K 36/62
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
62Nymphaeaceae (Water-lily family)
Applicants
  • 江苏中兴药业有限公司 JIANG SU ZHONGXING PHARM.CO., LTD [CN]/[CN]
Inventors
  • 武俊明 WU, Junming
Agents
  • 北京商专永信知识产权代理事务所(普通合伙) INTELIGHT IP LAW FIRM
Priority Data
202010363217.430.04.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) METHOD FOR PREPARING COMPOUND-TYPE TABLETS FOR PROTECTING LIVER AND DISPELLING EFFECTS OF ALCOHOL
(FR) PROCÉDÉ DE PRÉPARATION DE COMPRIMÉS DE TYPE COMPOSÉ POUR LA PROTECTION DU FOIE ET LA SUPPRESSION DES EFFETS DE L'ALCOOL
(ZH) 一种复合型保肝解酒片的制备方法
Abstract
(EN) Provided is a method for preparing compound-type tablets for protecting the liver and dispelling the effects of alcohol. Firstly, silibinin and cyclodextrin are prepared into silibinin microcapsules to improve the water solubility of silibinin, and then the microcapsules are used together with extracts of lotus leaves, reed rhizome, dandelion and Cordyceps mycelium to enable the prepared compound-type tablets for protecting the liver and dispelling the effects of alcohol to alleviate, within a shorter time, liver and kidney damage caused by excessive drinking.
(FR) L'invention concerne un procédé de préparation de comprimés de type composé pour la protection du foie et la suppression des effets de l'alcool. D'une part, la silibinine et la cyclodextrine sont préparées en microcapsules de silibinine pour améliorer la solubilité dans l'eau de la silibinine, puis les microcapsules sont utilisées avec des extraits de feuilles de lotus, de rhizome de roseau, de pissenlit et de mycélium de cordyceps pour permettre aux comprimés de type composé préparés pour la protection du foie et la suppression des effets de l'alcool d'atténuer, dans un délai plus court, les dommages au foie et aux reins causés par une consommation excessive d'alcool.
(ZH) 一种复合型保肝解酒片的制备方法,首先将水飞蓟宾和环糊精一起制备成水飞蓟宾微囊来提升水飞蓟宾的水溶性,再与荷叶、芦根、蒲公英以及虫草菌丝体的提取物一起使用,使制备的复合型保肝解酒片能在较短的时间里缓解因饮酒过度导致的肝肾损伤。
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