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1. WO2021216667 - ANTIBODIES TO CHITINASE 3-LIKE-1 AND METHODS OF USE THEREFOR

Publication Number WO/2021/216667
Publication Date 28.10.2021
International Application No. PCT/US2021/028338
International Filing Date 21.04.2021
IPC
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/40 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40against enzymes
C12 1/34
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/844
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
844Liver
C07K 16/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
40against enzymes
C07K 2317/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
C07K 2317/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applicants
  • THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US]/[US]
Inventors
  • JU, Cynthia
  • JEONG, Jongmin
  • SHAN, Zhao
  • LI, Leike
  • ZHANG, Ningyan
  • AN, Zhiqiang
Agents
  • HIGHLANDER, Steven L.
Priority Data
63/013,08721.04.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODIES TO CHITINASE 3-LIKE-1 AND METHODS OF USE THEREFOR
(FR) ANTICORPS DIRIGÉS CONTRE LA CHITINASE 3-LIKE -1 ET LEURS MÉTHODES D'UTILISATION
Abstract
(EN) Provided herein are antibodies binding to CHI3L1 and the uses of the antibodies in detecting and treating cancer and for treating hepatotoxicity.
(FR) L'invention concerne des anticorps se liant à CHI3L1 et les utilisations des anticorps dans la détection et le traitement du cancer et pour le traitement de l'hépatotoxicité.
Latest bibliographic data on file with the International Bureau